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JNK pathway inhibition selectively primes pancreatic cancer stem cells to TRAIL-induced apoptosis without affecting the physiology of normal tissue resident stem cells
OBJECTIVE: Successful treatment of solid cancers mandates targeting cancer stem cells (CSC) without impact on the physiology of normal tissue resident stem cells. C-Jun N-terminal kinase (JNK) signaling has been shown to be of importance in cancer. We test whether JNK inhibition would sensitize panc...
Autores principales: | Recio-Boiles, Alejandro, Ilmer, Matthias, Rhea, P. Robyn, Kettlun, Claudia, Heinemann, Mitja L., Ruetering, Jennifer, Vykoukal, Jody, Alt, Eckhard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891091/ https://www.ncbi.nlm.nih.gov/pubmed/26840266 http://dx.doi.org/10.18632/oncotarget.7066 |
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