Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival

As tumors accumulate genetic alterations, an evolutionary process occurs in which genetically distinct subclonal populations of cells co-exist, resulting in intratumor genetic heterogeneity (ITH). The clinical implications of ITH remain poorly defined. Data are limited with respect to whether ITH is...

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Detalles Bibliográficos
Autores principales: Morris, Luc G.T., Riaz, Nadeem, Desrichard, Alexis, Şenbabaoğlu, Yasin, Hakimi, A. Ari, Makarov, Vladimir, Reis-Filho, Jorge S., Chan, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891103/
https://www.ncbi.nlm.nih.gov/pubmed/26840267
http://dx.doi.org/10.18632/oncotarget.7067

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