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ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3
Receptor tyrosine kinases of the HER-family are involved in the development and progression of multiple epithelial tumors, and have consequently become widely used targets for new anti-cancer therapies. Trastuzumab, an antibody against HER2, has shown potent growth inhibitory effects on HER2 overexp...
Autores principales: | Ebbing, Eva A., Medema, Jan Paul, Damhofer, Helene, Meijer, Sybren L., Krishnadath, Kausilia K., van Berge Henegouwen, Mark I., Bijlsma, Maarten F., van Laarhoven, Hanneke W. M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891117/ https://www.ncbi.nlm.nih.gov/pubmed/26863569 http://dx.doi.org/10.18632/oncotarget.7200 |
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