Invasive mouse gastric adenocarcinomas arising from Lgr5+ stem cells are dependent on crosstalk between the Hedgehog/GLI2 and mTOR pathways

Gastric adenocarcinoma is the third most common cause of cancer-related death worldwide. Here we report a novel, highly-penetrant mouse model of invasive gastric cancer arising from deregulated Hedgehog/Gli2 signaling targeted to Lgr5-expressing stem cells in adult stomach. Tumor development progres...

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Detalles Bibliográficos
Autores principales: Syu, Li-Jyun, Zhao, Xinyi, Zhang, Yaqing, Grachtchouk, Marina, Demitrack, Elise, Ermilov, Alexandre, Wilbert, Dawn M., Zheng, Xinlei, Kaatz, Ashley, Greenson, Joel K., Gumucio, Deborah L., Merchant, Juanita L., di Magliano, Marina Pasca, Samuelson, Linda C., Dlugosz, Andrzej A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891118/
https://www.ncbi.nlm.nih.gov/pubmed/26859571
http://dx.doi.org/10.18632/oncotarget.7182

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