Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer

Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patient...

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Detalles Bibliográficos
Autores principales: Andreoli, Silmara Cristiane da Silveira, Gasparini, Nina Jardim, de Carvalho, Gisele Pereira, Garicochea, Bernardo, Pogue, Robert Edward, de Andrade, Rosângela Vieira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2014
Materias:
Medical Developments
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891175/
https://www.ncbi.nlm.nih.gov/pubmed/25003938
http://dx.doi.org/10.1590/S1679-45082014MD2839
Descripción
Sumario:Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer.

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