Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer

Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patient...

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Autores principales: Andreoli, Silmara Cristiane da Silveira, Gasparini, Nina Jardim, de Carvalho, Gisele Pereira, Garicochea, Bernardo, Pogue, Robert Edward, de Andrade, Rosângela Vieira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2014
Materias:
Medical Developments
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891175/
https://www.ncbi.nlm.nih.gov/pubmed/25003938
http://dx.doi.org/10.1590/S1679-45082014MD2839
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author Andreoli, Silmara Cristiane da Silveira
Gasparini, Nina Jardim
de Carvalho, Gisele Pereira
Garicochea, Bernardo
Pogue, Robert Edward
de Andrade, Rosângela Vieira
author_facet Andreoli, Silmara Cristiane da Silveira
Gasparini, Nina Jardim
de Carvalho, Gisele Pereira
Garicochea, Bernardo
Pogue, Robert Edward
de Andrade, Rosângela Vieira
author_sort Andreoli, Silmara Cristiane da Silveira
collection PubMed
description Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer.
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spelling pubmed-48911752016-08-10 Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer Andreoli, Silmara Cristiane da Silveira Gasparini, Nina Jardim de Carvalho, Gisele Pereira Garicochea, Bernardo Pogue, Robert Edward de Andrade, Rosângela Vieira Einstein (Sao Paulo) Medical Developments Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2014 /pmc/articles/PMC4891175/ /pubmed/25003938 http://dx.doi.org/10.1590/S1679-45082014MD2839 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Medical Developments
Andreoli, Silmara Cristiane da Silveira
Gasparini, Nina Jardim
de Carvalho, Gisele Pereira
Garicochea, Bernardo
Pogue, Robert Edward
de Andrade, Rosângela Vieira
Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_full Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_fullStr Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_full_unstemmed Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_short Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer
title_sort use of micrornas in directing therapy and evaluating treatment response in colorectal cancer
topic Medical Developments
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891175/
https://www.ncbi.nlm.nih.gov/pubmed/25003938
http://dx.doi.org/10.1590/S1679-45082014MD2839
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