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Dmrt1 polymorphism covaries with sex‐determination patterns in Rana temporaria

Patterns of sex‐chromosome differentiation and gonadal development have been shown to vary among populations of Rana temporaria along a latitudinal transect in Sweden. Frogs from the northern‐boreal population of Ammarnäs displayed well‐differentiated X and Y haplotypes, early gonadal differentiatio...

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Autores principales: Ma, Wen‐Juan, Rodrigues, Nicolas, Sermier, Roberto, Brelsford, Alan, Perrin, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891206/
https://www.ncbi.nlm.nih.gov/pubmed/27551369
http://dx.doi.org/10.1002/ece3.2209
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author Ma, Wen‐Juan
Rodrigues, Nicolas
Sermier, Roberto
Brelsford, Alan
Perrin, Nicolas
author_facet Ma, Wen‐Juan
Rodrigues, Nicolas
Sermier, Roberto
Brelsford, Alan
Perrin, Nicolas
author_sort Ma, Wen‐Juan
collection PubMed
description Patterns of sex‐chromosome differentiation and gonadal development have been shown to vary among populations of Rana temporaria along a latitudinal transect in Sweden. Frogs from the northern‐boreal population of Ammarnäs displayed well‐differentiated X and Y haplotypes, early gonadal differentiation, and a perfect match between phenotypic and genotypic sex. In contrast, no differentiated Y haplotypes could be detected in the southern population of Tvedöra, where juveniles furthermore showed delayed gonadal differentiation. Here, we show that Dmrt1, a gene that plays a key role in sex determination and sexual development across all metazoans, displays significant sex differentiation in Tvedöra, with a Y‐specific haplotype distinct from Ammarnäs. The differential segment is not only much shorter in Tvedöra than in Ammarnäs, it is also less differentiated and associates with both delayed gonadal differentiation and imperfect match between phenotypic and genotypic sex. Whereas Tvedöra juveniles with a local Y haplotype tend to ultimately develop as males, those without it may nevertheless become functional XX males, but with strongly female‐biased progeny. Our findings suggest that the variance in patterns of sex determination documented in common frogs might result from a genetic polymorphism within a small genomic region that contains Dmrt1. They also substantiate the view that recurrent convergences of sex determination toward a limited set of chromosome pairs may result from the co‐option of small genomic regions that harbor key genes from the sex‐determination pathway.
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spelling pubmed-48912062016-08-22 Dmrt1 polymorphism covaries with sex‐determination patterns in Rana temporaria Ma, Wen‐Juan Rodrigues, Nicolas Sermier, Roberto Brelsford, Alan Perrin, Nicolas Ecol Evol Original Research Patterns of sex‐chromosome differentiation and gonadal development have been shown to vary among populations of Rana temporaria along a latitudinal transect in Sweden. Frogs from the northern‐boreal population of Ammarnäs displayed well‐differentiated X and Y haplotypes, early gonadal differentiation, and a perfect match between phenotypic and genotypic sex. In contrast, no differentiated Y haplotypes could be detected in the southern population of Tvedöra, where juveniles furthermore showed delayed gonadal differentiation. Here, we show that Dmrt1, a gene that plays a key role in sex determination and sexual development across all metazoans, displays significant sex differentiation in Tvedöra, with a Y‐specific haplotype distinct from Ammarnäs. The differential segment is not only much shorter in Tvedöra than in Ammarnäs, it is also less differentiated and associates with both delayed gonadal differentiation and imperfect match between phenotypic and genotypic sex. Whereas Tvedöra juveniles with a local Y haplotype tend to ultimately develop as males, those without it may nevertheless become functional XX males, but with strongly female‐biased progeny. Our findings suggest that the variance in patterns of sex determination documented in common frogs might result from a genetic polymorphism within a small genomic region that contains Dmrt1. They also substantiate the view that recurrent convergences of sex determination toward a limited set of chromosome pairs may result from the co‐option of small genomic regions that harbor key genes from the sex‐determination pathway. John Wiley and Sons Inc. 2016-05-30 /pmc/articles/PMC4891206/ /pubmed/27551369 http://dx.doi.org/10.1002/ece3.2209 Text en © 2016 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Ma, Wen‐Juan
Rodrigues, Nicolas
Sermier, Roberto
Brelsford, Alan
Perrin, Nicolas
Dmrt1 polymorphism covaries with sex‐determination patterns in Rana temporaria
title Dmrt1 polymorphism covaries with sex‐determination patterns in Rana temporaria
title_full Dmrt1 polymorphism covaries with sex‐determination patterns in Rana temporaria
title_fullStr Dmrt1 polymorphism covaries with sex‐determination patterns in Rana temporaria
title_full_unstemmed Dmrt1 polymorphism covaries with sex‐determination patterns in Rana temporaria
title_short Dmrt1 polymorphism covaries with sex‐determination patterns in Rana temporaria
title_sort dmrt1 polymorphism covaries with sex‐determination patterns in rana temporaria
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891206/
https://www.ncbi.nlm.nih.gov/pubmed/27551369
http://dx.doi.org/10.1002/ece3.2209
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