Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells

Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation,...

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Autores principales: Cobellis, Gilda, Meccariello, Rosaria, Chianese, Rosanna, Chioccarelli, Teresa, Fasano, Silvia, Pierantoni, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891325/
https://www.ncbi.nlm.nih.gov/pubmed/27375550
http://dx.doi.org/10.3389/fendo.2016.00047
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author Cobellis, Gilda
Meccariello, Rosaria
Chianese, Rosanna
Chioccarelli, Teresa
Fasano, Silvia
Pierantoni, Riccardo
author_facet Cobellis, Gilda
Meccariello, Rosaria
Chianese, Rosanna
Chioccarelli, Teresa
Fasano, Silvia
Pierantoni, Riccardo
author_sort Cobellis, Gilda
collection PubMed
description Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, spermiogenesis, sperm quality, and maturation. In this short review, we provide a summary of the insights concerning neuroendocrine CB1 activity in male reproduction focusing on adult Leydig cell ontogenesis and steroid biosynthesis.
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spelling pubmed-48913252016-07-01 Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells Cobellis, Gilda Meccariello, Rosaria Chianese, Rosanna Chioccarelli, Teresa Fasano, Silvia Pierantoni, Riccardo Front Endocrinol (Lausanne) Endocrinology Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, spermiogenesis, sperm quality, and maturation. In this short review, we provide a summary of the insights concerning neuroendocrine CB1 activity in male reproduction focusing on adult Leydig cell ontogenesis and steroid biosynthesis. Frontiers Media S.A. 2016-06-03 /pmc/articles/PMC4891325/ /pubmed/27375550 http://dx.doi.org/10.3389/fendo.2016.00047 Text en Copyright © 2016 Cobellis, Meccariello, Chianese, Chioccarelli, Fasano and Pierantoni. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Cobellis, Gilda
Meccariello, Rosaria
Chianese, Rosanna
Chioccarelli, Teresa
Fasano, Silvia
Pierantoni, Riccardo
Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells
title Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells
title_full Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells
title_fullStr Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells
title_full_unstemmed Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells
title_short Effects of Neuroendocrine CB1 Activity on Adult Leydig Cells
title_sort effects of neuroendocrine cb1 activity on adult leydig cells
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891325/
https://www.ncbi.nlm.nih.gov/pubmed/27375550
http://dx.doi.org/10.3389/fendo.2016.00047
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