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Full-length LGR5-positive cells have chemoresistant characteristics in colorectal cancer

BACKGROUND: Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a target of Wnt signalling and considered both a cancer stem cell marker and intestinal stem cell marker. We found first some splice variants of LGR5 in human intestine and elucidated the functional feature of full-len...

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Detalles Bibliográficos
Autores principales:	Osawa, Hideki, Takahashi, Hidekazu, Nishimura, Junichi, Ohta, Katsuya, Haraguchi, Naotsugu, Hata, Taishi, Yamamoto, Hirofumi, Mizushima, Tsunekazu, Takemasa, Ichiro, Doki, Yuichiro, Mori, Masaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891500/ https://www.ncbi.nlm.nih.gov/pubmed/27140312 http://dx.doi.org/10.1038/bjc.2016.112

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