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Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative

BACKGROUND: Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death. METHODS: The DII was calculated f...

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Autores principales: Tabung, Fred K, Steck, Susan E, Liese, Angela D, Zhang, Jiajia, Ma, Yunsheng, Caan, Bette, Chlebowski, Rowan T, Freudenheim, Jo L, Hou, Lifang, Mossavar-Rahmani, Yasmin, Shivappa, Nitin, Vitolins, Mara Z, Wactawski-Wende, Jean, Ockene, Judith K, Hébert, James R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891517/
https://www.ncbi.nlm.nih.gov/pubmed/27100730
http://dx.doi.org/10.1038/bjc.2016.98
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author Tabung, Fred K
Steck, Susan E
Liese, Angela D
Zhang, Jiajia
Ma, Yunsheng
Caan, Bette
Chlebowski, Rowan T
Freudenheim, Jo L
Hou, Lifang
Mossavar-Rahmani, Yasmin
Shivappa, Nitin
Vitolins, Mara Z
Wactawski-Wende, Jean
Ockene, Judith K
Hébert, James R
author_facet Tabung, Fred K
Steck, Susan E
Liese, Angela D
Zhang, Jiajia
Ma, Yunsheng
Caan, Bette
Chlebowski, Rowan T
Freudenheim, Jo L
Hou, Lifang
Mossavar-Rahmani, Yasmin
Shivappa, Nitin
Vitolins, Mara Z
Wactawski-Wende, Jean
Ockene, Judith K
Hébert, James R
author_sort Tabung, Fred K
collection PubMed
description BACKGROUND: Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death. METHODS: The DII was calculated from a baseline food frequency questionnaire in 122 788 postmenopausal women, enrolled from 1993 to 1998 with no prior cancer, and followed until 29 August 2014. With median follow-up of 16.02 years, there were 7495 breast cancer cases and 667 breast cancer deaths. We used Cox regression to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by DII quintiles (Q) for incidence of overall breast cancer, breast cancer subtypes, and deaths from breast cancer. The lowest quintile (representing the most anti-inflammatory diet) was the reference. RESULTS: The DII was not associated with incidence of overall breast cancer (HR(Q5vsQ1), 0.99; 95% CI, 0.91–1.07; P(trend)=0.83 for overall breast cancer). In a full cohort analysis, a higher risk of death from breast cancer was associated with consumption of more pro-inflammatory diets at baseline, after controlling for multiple potential confounders (HR(Q5vsQ1), 1.33; 95% CI, 1.01–1.76; P(trend)=0.03). CONCLUSIONS: Future studies are needed to examine the inflammatory potential of post-diagnosis diet given the suggestion from the current study that dietary inflammatory potential before diagnosis is related to breast cancer death.
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spelling pubmed-48915172017-05-24 Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative Tabung, Fred K Steck, Susan E Liese, Angela D Zhang, Jiajia Ma, Yunsheng Caan, Bette Chlebowski, Rowan T Freudenheim, Jo L Hou, Lifang Mossavar-Rahmani, Yasmin Shivappa, Nitin Vitolins, Mara Z Wactawski-Wende, Jean Ockene, Judith K Hébert, James R Br J Cancer Epidemiology BACKGROUND: Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death. METHODS: The DII was calculated from a baseline food frequency questionnaire in 122 788 postmenopausal women, enrolled from 1993 to 1998 with no prior cancer, and followed until 29 August 2014. With median follow-up of 16.02 years, there were 7495 breast cancer cases and 667 breast cancer deaths. We used Cox regression to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by DII quintiles (Q) for incidence of overall breast cancer, breast cancer subtypes, and deaths from breast cancer. The lowest quintile (representing the most anti-inflammatory diet) was the reference. RESULTS: The DII was not associated with incidence of overall breast cancer (HR(Q5vsQ1), 0.99; 95% CI, 0.91–1.07; P(trend)=0.83 for overall breast cancer). In a full cohort analysis, a higher risk of death from breast cancer was associated with consumption of more pro-inflammatory diets at baseline, after controlling for multiple potential confounders (HR(Q5vsQ1), 1.33; 95% CI, 1.01–1.76; P(trend)=0.03). CONCLUSIONS: Future studies are needed to examine the inflammatory potential of post-diagnosis diet given the suggestion from the current study that dietary inflammatory potential before diagnosis is related to breast cancer death. Nature Publishing Group 2016-05-24 2016-04-21 /pmc/articles/PMC4891517/ /pubmed/27100730 http://dx.doi.org/10.1038/bjc.2016.98 Text en Copyright © 2016 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Epidemiology
Tabung, Fred K
Steck, Susan E
Liese, Angela D
Zhang, Jiajia
Ma, Yunsheng
Caan, Bette
Chlebowski, Rowan T
Freudenheim, Jo L
Hou, Lifang
Mossavar-Rahmani, Yasmin
Shivappa, Nitin
Vitolins, Mara Z
Wactawski-Wende, Jean
Ockene, Judith K
Hébert, James R
Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative
title Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative
title_full Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative
title_fullStr Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative
title_full_unstemmed Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative
title_short Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative
title_sort association between dietary inflammatory potential and breast cancer incidence and death: results from the women's health initiative
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891517/
https://www.ncbi.nlm.nih.gov/pubmed/27100730
http://dx.doi.org/10.1038/bjc.2016.98
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