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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man

Orexin neuropeptides regulate sleep/wake through orexin receptors (OX(1)R, OX(2)R); OX(2)R is the predominant mediator of arousal promotion. The potential for single OX(2)R antagonism to effectively promote sleep has yet to be demonstrated in humans. MK-1064 is an OX(2)R-single antagonist. Preclinic...

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Detalles Bibliográficos
Autores principales:	Gotter, Anthony L., Forman, Mark S., Harrell, Charles M., Stevens, Joanne, Svetnik, Vladimir, Yee, Ka Lai, Li, Xiaodong, Roecker, Anthony J., Fox, Steven V., Tannenbaum, Pamela L., Garson, Susan L., Lepeleire, Inge De, Calder, Nicole, Rosen, Laura, Struyk, Arie, Coleman, Paul J., Herring, W. Joseph, Renger, John J., Winrow, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891657/ https://www.ncbi.nlm.nih.gov/pubmed/27256922 http://dx.doi.org/10.1038/srep27147

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