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Pro-apoptotic Bax molecules densely populate the edges of membrane pores

How the pro-apoptotic Bax protein permeabilizes the mitochondrial outer membrane is not fully understood. Previously, using cryo-electron microscopy (cryo-EM), we showed that activated Bax forms large, growing pores. Whether formed in liposomes or in mitochondrial outer membranes, Bax-induced pores...

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Detalles Bibliográficos
Autores principales:	Kuwana, Tomomi, Olson, Norman H., Kiosses, William B., Peters, Bjoern, Newmeyer, Donald D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891688/ https://www.ncbi.nlm.nih.gov/pubmed/27255832 http://dx.doi.org/10.1038/srep27299

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