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Gene switching rate determines response to extrinsic perturbations in the self-activation transcriptional network motif
Gene switching dynamics is a major source of randomness in genetic networks, also in the case of large concentrations of the transcription factors. In this work, we consider a common network motif - the positive feedback of a transcription factor on its own synthesis - and assess its response to ext...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891709/ https://www.ncbi.nlm.nih.gov/pubmed/27256916 http://dx.doi.org/10.1038/srep26980 |