Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7

The design of potent and specific peptide inhibitors to therapeutic targets is of enormous utility for both proof-of-concept studies and for the development of potential new therapeutics. Grb7 is a key signaling molecule in the progression of HER2 positive and triple negative breast cancers. Here we...

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Detalles Bibliográficos
Autores principales: Gunzburg, Menachem J., Kulkarni, Ketav, Watson, Gabrielle M., Ambaye, Nigus D., Del Borgo, Mark P., Brandt, Rebecca, Pero, Stephanie C., Perlmutter, Patrick, Wilce, Matthew C. J., Wilce, Jacqueline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891710/
https://www.ncbi.nlm.nih.gov/pubmed/27257138
http://dx.doi.org/10.1038/srep27060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891710/
https://www.ncbi.nlm.nih.gov/pubmed/27257138
http://dx.doi.org/10.1038/srep27060

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