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The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria
The endothelial protein C receptor (EPCR) appears to play an important role in Plasmodium falciparum endothelial cell binding in severe malaria (SM). Despite consistent findings of elevated soluble EPCR (sEPCR) in other infectious diseases, field studies to date have provided conflicting data about...
Autores principales: | Shabani, Estela, Opoka, Robert O., Bangirana, Paul, Park, Gregory S., Vercellotti, Gregory M., Guan, Weihua, Hodges, James S., Lavstsen, Thomas, John, Chandy C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891778/ https://www.ncbi.nlm.nih.gov/pubmed/27255786 http://dx.doi.org/10.1038/srep27084 |
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