Loss of functional OPA1 unbalances redox state: implications in dominant optic atrophy pathogenesis

OBJECTIVE: OPA1 mutations cause protein haploinsufficiency leading to dominant optic atrophy (DOA), an incurable retinopathy with variable severity. Up to 20% of patients also develop extraocular neurological complications. The mechanisms that cause this optic atrophy or its syndromic forms are stil...

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Detalles Bibliográficos
Autores principales: Millet, Aurélie M. C., Bertholet, Ambre M., Daloyau, Marlène, Reynier, Pascal, Galinier, Anne, Devin, Anne, Wissinguer, Bernd, Belenguer, Pascale, Davezac, Noélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891995/
https://www.ncbi.nlm.nih.gov/pubmed/27547769
http://dx.doi.org/10.1002/acn3.305

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