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Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study

Objective: This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-β(1), platelet-derived growth factor (PDGF)-BB, and interleukin (IL)-8 levels in pal...

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Autores principales: Keskiner, Ilker, Lutfioğlu, Muge, Aydogdu, Ahmet, Saygun, N. Isil, Serdar, Muhittin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892223/
https://www.ncbi.nlm.nih.gov/pubmed/27088277
http://dx.doi.org/10.1089/pho.2016.4094
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author Keskiner, Ilker
Lutfioğlu, Muge
Aydogdu, Ahmet
Saygun, N. Isil
Serdar, Muhittin A.
author_facet Keskiner, Ilker
Lutfioğlu, Muge
Aydogdu, Ahmet
Saygun, N. Isil
Serdar, Muhittin A.
author_sort Keskiner, Ilker
collection PubMed
description Objective: This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-β(1), platelet-derived growth factor (PDGF)-BB, and interleukin (IL)-8 levels in palatal wound fluid (PWF). Material and methods: Thirty patients were selected and randomly assigned to receive PBM (laser group) or PBM sham (sham group) in the palatine area after FGG harvesting. A neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (1064 nm) was applied to the test sites immediately after surgery and every 24 h thereafter for 4 days. PWF was collected on Days 7 and 12, and PWF TGF-β(1), PDGF-BB, and IL-8 levels were analyzed by enzyme-linked immunosorbent assays (ELISA). Results: PWF TGF-β(1), PDGF-BB, and IL-8 levels were significantly lower on Day 12 than on Day 7 for both groups. PWF TGF-β(1), PDGF-BB, and IL-8 levels of the laser group were significantly higher than those of sham group on Day 7 (p < 0.05). PWF TGF-β(1) levels were also significantly higher in laser group than in the sham group on Day 12; however, differences in PDGF-BB and IL-8 levels between groups on Day 12 were statistically nonsignificant. Conclusions: Observed increases in PWF TGF-β(1), PDGF-BB, and IL-8 levels suggest that PBM may accelerate wound healing by stimulating production of selected mediators.
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spelling pubmed-48922232016-06-07 Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study Keskiner, Ilker Lutfioğlu, Muge Aydogdu, Ahmet Saygun, N. Isil Serdar, Muhittin A. Photomed Laser Surg Original Research Objective: This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-β(1), platelet-derived growth factor (PDGF)-BB, and interleukin (IL)-8 levels in palatal wound fluid (PWF). Material and methods: Thirty patients were selected and randomly assigned to receive PBM (laser group) or PBM sham (sham group) in the palatine area after FGG harvesting. A neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (1064 nm) was applied to the test sites immediately after surgery and every 24 h thereafter for 4 days. PWF was collected on Days 7 and 12, and PWF TGF-β(1), PDGF-BB, and IL-8 levels were analyzed by enzyme-linked immunosorbent assays (ELISA). Results: PWF TGF-β(1), PDGF-BB, and IL-8 levels were significantly lower on Day 12 than on Day 7 for both groups. PWF TGF-β(1), PDGF-BB, and IL-8 levels of the laser group were significantly higher than those of sham group on Day 7 (p < 0.05). PWF TGF-β(1) levels were also significantly higher in laser group than in the sham group on Day 12; however, differences in PDGF-BB and IL-8 levels between groups on Day 12 were statistically nonsignificant. Conclusions: Observed increases in PWF TGF-β(1), PDGF-BB, and IL-8 levels suggest that PBM may accelerate wound healing by stimulating production of selected mediators. Mary Ann Liebert, Inc. 2016-06-01 /pmc/articles/PMC4892223/ /pubmed/27088277 http://dx.doi.org/10.1089/pho.2016.4094 Text en © Ilker Keskiner et al., 2016; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Research
Keskiner, Ilker
Lutfioğlu, Muge
Aydogdu, Ahmet
Saygun, N. Isil
Serdar, Muhittin A.
Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study
title Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study
title_full Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study
title_fullStr Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study
title_full_unstemmed Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study
title_short Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study
title_sort effect of photobiomodulation on transforming growth factor-β(1), platelet-derived growth factor-bb, and interleukin-8 release in palatal wounds after free gingival graft harvesting: a randomized clinical study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892223/
https://www.ncbi.nlm.nih.gov/pubmed/27088277
http://dx.doi.org/10.1089/pho.2016.4094
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