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Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study
Objective: This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-β(1), platelet-derived growth factor (PDGF)-BB, and interleukin (IL)-8 levels in pal...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892223/ https://www.ncbi.nlm.nih.gov/pubmed/27088277 http://dx.doi.org/10.1089/pho.2016.4094 |
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author | Keskiner, Ilker Lutfioğlu, Muge Aydogdu, Ahmet Saygun, N. Isil Serdar, Muhittin A. |
author_facet | Keskiner, Ilker Lutfioğlu, Muge Aydogdu, Ahmet Saygun, N. Isil Serdar, Muhittin A. |
author_sort | Keskiner, Ilker |
collection | PubMed |
description | Objective: This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-β(1), platelet-derived growth factor (PDGF)-BB, and interleukin (IL)-8 levels in palatal wound fluid (PWF). Material and methods: Thirty patients were selected and randomly assigned to receive PBM (laser group) or PBM sham (sham group) in the palatine area after FGG harvesting. A neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (1064 nm) was applied to the test sites immediately after surgery and every 24 h thereafter for 4 days. PWF was collected on Days 7 and 12, and PWF TGF-β(1), PDGF-BB, and IL-8 levels were analyzed by enzyme-linked immunosorbent assays (ELISA). Results: PWF TGF-β(1), PDGF-BB, and IL-8 levels were significantly lower on Day 12 than on Day 7 for both groups. PWF TGF-β(1), PDGF-BB, and IL-8 levels of the laser group were significantly higher than those of sham group on Day 7 (p < 0.05). PWF TGF-β(1) levels were also significantly higher in laser group than in the sham group on Day 12; however, differences in PDGF-BB and IL-8 levels between groups on Day 12 were statistically nonsignificant. Conclusions: Observed increases in PWF TGF-β(1), PDGF-BB, and IL-8 levels suggest that PBM may accelerate wound healing by stimulating production of selected mediators. |
format | Online Article Text |
id | pubmed-4892223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Mary Ann Liebert, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48922232016-06-07 Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study Keskiner, Ilker Lutfioğlu, Muge Aydogdu, Ahmet Saygun, N. Isil Serdar, Muhittin A. Photomed Laser Surg Original Research Objective: This study evaluated the impact of photobiomodulation (PBM) on the healing of the donor palatal area following free gingival graft (FGG) harvesting by examining changes in transforming growth factor (TGF)-β(1), platelet-derived growth factor (PDGF)-BB, and interleukin (IL)-8 levels in palatal wound fluid (PWF). Material and methods: Thirty patients were selected and randomly assigned to receive PBM (laser group) or PBM sham (sham group) in the palatine area after FGG harvesting. A neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (1064 nm) was applied to the test sites immediately after surgery and every 24 h thereafter for 4 days. PWF was collected on Days 7 and 12, and PWF TGF-β(1), PDGF-BB, and IL-8 levels were analyzed by enzyme-linked immunosorbent assays (ELISA). Results: PWF TGF-β(1), PDGF-BB, and IL-8 levels were significantly lower on Day 12 than on Day 7 for both groups. PWF TGF-β(1), PDGF-BB, and IL-8 levels of the laser group were significantly higher than those of sham group on Day 7 (p < 0.05). PWF TGF-β(1) levels were also significantly higher in laser group than in the sham group on Day 12; however, differences in PDGF-BB and IL-8 levels between groups on Day 12 were statistically nonsignificant. Conclusions: Observed increases in PWF TGF-β(1), PDGF-BB, and IL-8 levels suggest that PBM may accelerate wound healing by stimulating production of selected mediators. Mary Ann Liebert, Inc. 2016-06-01 /pmc/articles/PMC4892223/ /pubmed/27088277 http://dx.doi.org/10.1089/pho.2016.4094 Text en © Ilker Keskiner et al., 2016; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Research Keskiner, Ilker Lutfioğlu, Muge Aydogdu, Ahmet Saygun, N. Isil Serdar, Muhittin A. Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study |
title | Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study |
title_full | Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study |
title_fullStr | Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study |
title_full_unstemmed | Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study |
title_short | Effect of Photobiomodulation on Transforming Growth Factor-β(1), Platelet-Derived Growth Factor-BB, and Interleukin-8 Release in Palatal Wounds After Free Gingival Graft Harvesting: A Randomized Clinical Study |
title_sort | effect of photobiomodulation on transforming growth factor-β(1), platelet-derived growth factor-bb, and interleukin-8 release in palatal wounds after free gingival graft harvesting: a randomized clinical study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892223/ https://www.ncbi.nlm.nih.gov/pubmed/27088277 http://dx.doi.org/10.1089/pho.2016.4094 |
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