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A D-Shaped Bileaflet Bioprosthesis which Replicates Physiological Left Ventricular Flow Patterns

Prior studies have shown that in a healthy heart, there exist a large asymmetric vortex structure that aids in establishing a steady flow field in the left ventricle. However, the implantation of existing artificial heart valves at the mitral position is found to have a negative effect on this physi...

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Detalles Bibliográficos
Autores principales: Tan, Sean Guo-Dong, Kim, Sangho, Hon, Jimmy Kim Fatt, Leo, Hwa Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892640/
https://www.ncbi.nlm.nih.gov/pubmed/27258099
http://dx.doi.org/10.1371/journal.pone.0156580
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author Tan, Sean Guo-Dong
Kim, Sangho
Hon, Jimmy Kim Fatt
Leo, Hwa Liang
author_facet Tan, Sean Guo-Dong
Kim, Sangho
Hon, Jimmy Kim Fatt
Leo, Hwa Liang
author_sort Tan, Sean Guo-Dong
collection PubMed
description Prior studies have shown that in a healthy heart, there exist a large asymmetric vortex structure that aids in establishing a steady flow field in the left ventricle. However, the implantation of existing artificial heart valves at the mitral position is found to have a negative effect on this physiological flow pattern. In light of this, a novel D-shaped bileaflet porcine bioprosthesis (GD valve) has been designed based on the native geometry mitral valve, with the hypothesis that biomimicry in valve design can restore physiological left ventricle flow patterns after valve implantation. An in-vitro experiment using two dimensional particle velocimetry imaging was carried out to determine the hemodynamic performance of the new bileaflet design and then compared to that of the well-established St. Jude Epic valve which functioned as a control in the experiment. Although both valves were found to have similar Reynolds shear stress and Turbulent Kinetic Energy levels, the novel D-shape valve was found to have lower turbulence intensity and greater mean kinetic energy conservation.
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spelling pubmed-48926402016-06-16 A D-Shaped Bileaflet Bioprosthesis which Replicates Physiological Left Ventricular Flow Patterns Tan, Sean Guo-Dong Kim, Sangho Hon, Jimmy Kim Fatt Leo, Hwa Liang PLoS One Research Article Prior studies have shown that in a healthy heart, there exist a large asymmetric vortex structure that aids in establishing a steady flow field in the left ventricle. However, the implantation of existing artificial heart valves at the mitral position is found to have a negative effect on this physiological flow pattern. In light of this, a novel D-shaped bileaflet porcine bioprosthesis (GD valve) has been designed based on the native geometry mitral valve, with the hypothesis that biomimicry in valve design can restore physiological left ventricle flow patterns after valve implantation. An in-vitro experiment using two dimensional particle velocimetry imaging was carried out to determine the hemodynamic performance of the new bileaflet design and then compared to that of the well-established St. Jude Epic valve which functioned as a control in the experiment. Although both valves were found to have similar Reynolds shear stress and Turbulent Kinetic Energy levels, the novel D-shape valve was found to have lower turbulence intensity and greater mean kinetic energy conservation. Public Library of Science 2016-06-03 /pmc/articles/PMC4892640/ /pubmed/27258099 http://dx.doi.org/10.1371/journal.pone.0156580 Text en © 2016 Tan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tan, Sean Guo-Dong
Kim, Sangho
Hon, Jimmy Kim Fatt
Leo, Hwa Liang
A D-Shaped Bileaflet Bioprosthesis which Replicates Physiological Left Ventricular Flow Patterns
title A D-Shaped Bileaflet Bioprosthesis which Replicates Physiological Left Ventricular Flow Patterns
title_full A D-Shaped Bileaflet Bioprosthesis which Replicates Physiological Left Ventricular Flow Patterns
title_fullStr A D-Shaped Bileaflet Bioprosthesis which Replicates Physiological Left Ventricular Flow Patterns
title_full_unstemmed A D-Shaped Bileaflet Bioprosthesis which Replicates Physiological Left Ventricular Flow Patterns
title_short A D-Shaped Bileaflet Bioprosthesis which Replicates Physiological Left Ventricular Flow Patterns
title_sort d-shaped bileaflet bioprosthesis which replicates physiological left ventricular flow patterns
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892640/
https://www.ncbi.nlm.nih.gov/pubmed/27258099
http://dx.doi.org/10.1371/journal.pone.0156580
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