A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure

Genetic variations affecting neural tube closure along the head result in malformations of the face and brain. Neural tube defects (NTDs) are among the most common birth defects in humans. We previously reported a mouse mutant called tuft that arose spontaneously in our wild-type 3H1 colony. Adult t...

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Detalles Bibliográficos
Autores principales: Fong, Keith S. K., Hufnagel, Robert B., Khadka, Vedbar S., Corley, Michael J., Maunakea, Alika K., Fogelgren, Ben, Ahmed, Zubair M., Lozanoff, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892663/
https://www.ncbi.nlm.nih.gov/pubmed/26989192
http://dx.doi.org/10.1242/dmm.024109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892663/
https://www.ncbi.nlm.nih.gov/pubmed/26989192
http://dx.doi.org/10.1242/dmm.024109

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