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A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure
Genetic variations affecting neural tube closure along the head result in malformations of the face and brain. Neural tube defects (NTDs) are among the most common birth defects in humans. We previously reported a mouse mutant called tuft that arose spontaneously in our wild-type 3H1 colony. Adult t...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892663/ https://www.ncbi.nlm.nih.gov/pubmed/26989192 http://dx.doi.org/10.1242/dmm.024109 |