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Core auditory processing deficits in primary progressive aphasia

The extent to which non-linguistic auditory processing deficits may contribute to the phenomenology of primary progressive aphasia is not established. Using non-linguistic stimuli devoid of meaning we assessed three key domains of auditory processing (pitch, timing and timbre) in a consecutive serie...

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Autores principales: Grube, Manon, Bruffaerts, Rose, Schaeverbeke, Jolien, Neyens, Veerle, De Weer, An-Sofie, Seghers, Alexandra, Bergmans, Bruno, Dries, Eva, Griffiths, Timothy D., Vandenberghe, Rik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892752/
https://www.ncbi.nlm.nih.gov/pubmed/27060523
http://dx.doi.org/10.1093/brain/aww067
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author Grube, Manon
Bruffaerts, Rose
Schaeverbeke, Jolien
Neyens, Veerle
De Weer, An-Sofie
Seghers, Alexandra
Bergmans, Bruno
Dries, Eva
Griffiths, Timothy D.
Vandenberghe, Rik
author_facet Grube, Manon
Bruffaerts, Rose
Schaeverbeke, Jolien
Neyens, Veerle
De Weer, An-Sofie
Seghers, Alexandra
Bergmans, Bruno
Dries, Eva
Griffiths, Timothy D.
Vandenberghe, Rik
author_sort Grube, Manon
collection PubMed
description The extent to which non-linguistic auditory processing deficits may contribute to the phenomenology of primary progressive aphasia is not established. Using non-linguistic stimuli devoid of meaning we assessed three key domains of auditory processing (pitch, timing and timbre) in a consecutive series of 18 patients with primary progressive aphasia (eight with semantic variant, six with non-fluent/agrammatic variant, and four with logopenic variant), as well as 28 age-matched healthy controls. We further examined whether performance on the psychoacoustic tasks in the three domains related to the patients’ speech and language and neuropsychological profile. At the group level, patients were significantly impaired in the three domains. Patients had the most marked deficits within the rhythm domain for the processing of short sequences of up to seven tones. Patients with the non-fluent variant showed the most pronounced deficits at the group and the individual level. A subset of patients with the semantic variant were also impaired, though less severely. The patients with the logopenic variant did not show any significant impairments. Significant deficits in the non-fluent and the semantic variant remained after partialling out effects of executive dysfunction. Performance on a subset of the psychoacoustic tests correlated with conventional verbal repetition tests. In sum, a core central auditory impairment exists in primary progressive aphasia for non-linguistic stimuli. While the non-fluent variant is clinically characterized by a motor speech deficit (output problem), perceptual processing of tone sequences is clearly deficient. This may indicate the co-occurrence in the non-fluent variant of a deficit in working memory for auditory objects. Parsimoniously we propose that auditory timing pathways are altered, which are used in common for processing acoustic sequence structure in both speech output and acoustic input.
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spelling pubmed-48927522016-06-07 Core auditory processing deficits in primary progressive aphasia Grube, Manon Bruffaerts, Rose Schaeverbeke, Jolien Neyens, Veerle De Weer, An-Sofie Seghers, Alexandra Bergmans, Bruno Dries, Eva Griffiths, Timothy D. Vandenberghe, Rik Brain Original Articles The extent to which non-linguistic auditory processing deficits may contribute to the phenomenology of primary progressive aphasia is not established. Using non-linguistic stimuli devoid of meaning we assessed three key domains of auditory processing (pitch, timing and timbre) in a consecutive series of 18 patients with primary progressive aphasia (eight with semantic variant, six with non-fluent/agrammatic variant, and four with logopenic variant), as well as 28 age-matched healthy controls. We further examined whether performance on the psychoacoustic tasks in the three domains related to the patients’ speech and language and neuropsychological profile. At the group level, patients were significantly impaired in the three domains. Patients had the most marked deficits within the rhythm domain for the processing of short sequences of up to seven tones. Patients with the non-fluent variant showed the most pronounced deficits at the group and the individual level. A subset of patients with the semantic variant were also impaired, though less severely. The patients with the logopenic variant did not show any significant impairments. Significant deficits in the non-fluent and the semantic variant remained after partialling out effects of executive dysfunction. Performance on a subset of the psychoacoustic tests correlated with conventional verbal repetition tests. In sum, a core central auditory impairment exists in primary progressive aphasia for non-linguistic stimuli. While the non-fluent variant is clinically characterized by a motor speech deficit (output problem), perceptual processing of tone sequences is clearly deficient. This may indicate the co-occurrence in the non-fluent variant of a deficit in working memory for auditory objects. Parsimoniously we propose that auditory timing pathways are altered, which are used in common for processing acoustic sequence structure in both speech output and acoustic input. Oxford University Press 2016-06 2016-04-09 /pmc/articles/PMC4892752/ /pubmed/27060523 http://dx.doi.org/10.1093/brain/aww067 Text en © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Grube, Manon
Bruffaerts, Rose
Schaeverbeke, Jolien
Neyens, Veerle
De Weer, An-Sofie
Seghers, Alexandra
Bergmans, Bruno
Dries, Eva
Griffiths, Timothy D.
Vandenberghe, Rik
Core auditory processing deficits in primary progressive aphasia
title Core auditory processing deficits in primary progressive aphasia
title_full Core auditory processing deficits in primary progressive aphasia
title_fullStr Core auditory processing deficits in primary progressive aphasia
title_full_unstemmed Core auditory processing deficits in primary progressive aphasia
title_short Core auditory processing deficits in primary progressive aphasia
title_sort core auditory processing deficits in primary progressive aphasia
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892752/
https://www.ncbi.nlm.nih.gov/pubmed/27060523
http://dx.doi.org/10.1093/brain/aww067
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