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A Pilot Study of Safety and Efficacy of Cranial Electrotherapy Stimulation in Treatment of Bipolar II Depression

This double-blind, sham-controlled study sought to investigate the effectiveness of cranial electrotherapy stimulation (CES) for the treatment of bipolar II depression (BD II). After randomization, the active group participants (n = 7) received 2 mA CES treatment for 20 minutes five days a week for...

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Autores principales: McClure, Deimante, Greenman, Samantha C., Koppolu, Siva Sundeep, Varvara, Maria, Yaseen, Zimri S., Galynker, Igor I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892785/
https://www.ncbi.nlm.nih.gov/pubmed/26414234
http://dx.doi.org/10.1097/NMD.0000000000000378
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author McClure, Deimante
Greenman, Samantha C.
Koppolu, Siva Sundeep
Varvara, Maria
Yaseen, Zimri S.
Galynker, Igor I.
author_facet McClure, Deimante
Greenman, Samantha C.
Koppolu, Siva Sundeep
Varvara, Maria
Yaseen, Zimri S.
Galynker, Igor I.
author_sort McClure, Deimante
collection PubMed
description This double-blind, sham-controlled study sought to investigate the effectiveness of cranial electrotherapy stimulation (CES) for the treatment of bipolar II depression (BD II). After randomization, the active group participants (n = 7) received 2 mA CES treatment for 20 minutes five days a week for 2 weeks, whereas the sham group (n = 9) had the CES device turned on and off. Symptom non-remitters from both groups received an additional 2 weeks of open-label active treatment. Active CES treatment but not sham treatment was associated with a significant decrease in the Beck Depression Inventory (BDI) scores from baseline to the second week (p = 0.003) maintaining significance until week 4 (p = 0.002). There was no difference between the groups in side effects frequency. The results of this small study indicate that CES may be a safe and effective treatment for BD II suggesting that further studies on safety and efficacy of CES may be warranted.
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spelling pubmed-48927852016-06-21 A Pilot Study of Safety and Efficacy of Cranial Electrotherapy Stimulation in Treatment of Bipolar II Depression McClure, Deimante Greenman, Samantha C. Koppolu, Siva Sundeep Varvara, Maria Yaseen, Zimri S. Galynker, Igor I. J Nerv Ment Dis Original Articles This double-blind, sham-controlled study sought to investigate the effectiveness of cranial electrotherapy stimulation (CES) for the treatment of bipolar II depression (BD II). After randomization, the active group participants (n = 7) received 2 mA CES treatment for 20 minutes five days a week for 2 weeks, whereas the sham group (n = 9) had the CES device turned on and off. Symptom non-remitters from both groups received an additional 2 weeks of open-label active treatment. Active CES treatment but not sham treatment was associated with a significant decrease in the Beck Depression Inventory (BDI) scores from baseline to the second week (p = 0.003) maintaining significance until week 4 (p = 0.002). There was no difference between the groups in side effects frequency. The results of this small study indicate that CES may be a safe and effective treatment for BD II suggesting that further studies on safety and efficacy of CES may be warranted. Lippincott Williams & Wilkins 2015-11 2015-11-12 /pmc/articles/PMC4892785/ /pubmed/26414234 http://dx.doi.org/10.1097/NMD.0000000000000378 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Original Articles
McClure, Deimante
Greenman, Samantha C.
Koppolu, Siva Sundeep
Varvara, Maria
Yaseen, Zimri S.
Galynker, Igor I.
A Pilot Study of Safety and Efficacy of Cranial Electrotherapy Stimulation in Treatment of Bipolar II Depression
title A Pilot Study of Safety and Efficacy of Cranial Electrotherapy Stimulation in Treatment of Bipolar II Depression
title_full A Pilot Study of Safety and Efficacy of Cranial Electrotherapy Stimulation in Treatment of Bipolar II Depression
title_fullStr A Pilot Study of Safety and Efficacy of Cranial Electrotherapy Stimulation in Treatment of Bipolar II Depression
title_full_unstemmed A Pilot Study of Safety and Efficacy of Cranial Electrotherapy Stimulation in Treatment of Bipolar II Depression
title_short A Pilot Study of Safety and Efficacy of Cranial Electrotherapy Stimulation in Treatment of Bipolar II Depression
title_sort pilot study of safety and efficacy of cranial electrotherapy stimulation in treatment of bipolar ii depression
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892785/
https://www.ncbi.nlm.nih.gov/pubmed/26414234
http://dx.doi.org/10.1097/NMD.0000000000000378
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