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Risk model in stage IB1-IIB cervical cancer with positive node after radical hysterectomy
The purpose of this study was to identify risk factors in patients with surgically treated node-positive IB1-IIB cervical cancer and to establish a risk model for disease-free survival (DFS) and overall survival (OS). A total of 170 patients who underwent radical hysterectomy and bilateral pelvic ly...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892859/ https://www.ncbi.nlm.nih.gov/pubmed/27313462 http://dx.doi.org/10.2147/OTT.S94151 |
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author | Chen, Zhilan Huang, Kecheng Lu, Zhiyong Deng, Song Xiong, Jiaqiang Huang, Jia Li, Xiong Tang, Fangxu Wang, Zhihao Sun, Haiying Wang, Lin Zhou, Shasha Wang, Xiaoli Jia, Yao Hu, Ting Gui, Juan Wan, Dongyi Ma, Ding Li, Shuang Wang, Shixuan |
author_facet | Chen, Zhilan Huang, Kecheng Lu, Zhiyong Deng, Song Xiong, Jiaqiang Huang, Jia Li, Xiong Tang, Fangxu Wang, Zhihao Sun, Haiying Wang, Lin Zhou, Shasha Wang, Xiaoli Jia, Yao Hu, Ting Gui, Juan Wan, Dongyi Ma, Ding Li, Shuang Wang, Shixuan |
author_sort | Chen, Zhilan |
collection | PubMed |
description | The purpose of this study was to identify risk factors in patients with surgically treated node-positive IB1-IIB cervical cancer and to establish a risk model for disease-free survival (DFS) and overall survival (OS). A total of 170 patients who underwent radical hysterectomy and bilateral pelvic lymphadenectomy as primary treatment for node-positive International Federation of Gynaecology and Obstetrics (FIGO) stage IB1-IIB cervical cancer from January 2002 to December 2008 were retrospectively analyzed. Five published risk models were evaluated in this population. The variables, including common iliac lymph node metastasis and parametrial invasion, were independent predictors of outcome in a multivariate analysis using a Cox regression model. Three distinct prognostic groups (low, intermediate, and high risk) were defined using these variables. Five-year DFS rates for the low-, intermediate-, and high-risk groups were 73.7%, 60.0%, and 25.0%, respectively (P<0.001), and 5-year OS rates were 81.9%, 42.8%, and 25.0%, respectively (P<0.001). The risk model derived in this study provides a novel means for assessing prognosis of patients with node-positive stage IB1-IIB cervical cancer. Future study will focus on external validation of the model and refinement of the risk scoring systems by adding new biologic markers. |
format | Online Article Text |
id | pubmed-4892859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48928592016-06-16 Risk model in stage IB1-IIB cervical cancer with positive node after radical hysterectomy Chen, Zhilan Huang, Kecheng Lu, Zhiyong Deng, Song Xiong, Jiaqiang Huang, Jia Li, Xiong Tang, Fangxu Wang, Zhihao Sun, Haiying Wang, Lin Zhou, Shasha Wang, Xiaoli Jia, Yao Hu, Ting Gui, Juan Wan, Dongyi Ma, Ding Li, Shuang Wang, Shixuan Onco Targets Ther Original Research The purpose of this study was to identify risk factors in patients with surgically treated node-positive IB1-IIB cervical cancer and to establish a risk model for disease-free survival (DFS) and overall survival (OS). A total of 170 patients who underwent radical hysterectomy and bilateral pelvic lymphadenectomy as primary treatment for node-positive International Federation of Gynaecology and Obstetrics (FIGO) stage IB1-IIB cervical cancer from January 2002 to December 2008 were retrospectively analyzed. Five published risk models were evaluated in this population. The variables, including common iliac lymph node metastasis and parametrial invasion, were independent predictors of outcome in a multivariate analysis using a Cox regression model. Three distinct prognostic groups (low, intermediate, and high risk) were defined using these variables. Five-year DFS rates for the low-, intermediate-, and high-risk groups were 73.7%, 60.0%, and 25.0%, respectively (P<0.001), and 5-year OS rates were 81.9%, 42.8%, and 25.0%, respectively (P<0.001). The risk model derived in this study provides a novel means for assessing prognosis of patients with node-positive stage IB1-IIB cervical cancer. Future study will focus on external validation of the model and refinement of the risk scoring systems by adding new biologic markers. Dove Medical Press 2016-05-27 /pmc/articles/PMC4892859/ /pubmed/27313462 http://dx.doi.org/10.2147/OTT.S94151 Text en © 2016 Chen et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Chen, Zhilan Huang, Kecheng Lu, Zhiyong Deng, Song Xiong, Jiaqiang Huang, Jia Li, Xiong Tang, Fangxu Wang, Zhihao Sun, Haiying Wang, Lin Zhou, Shasha Wang, Xiaoli Jia, Yao Hu, Ting Gui, Juan Wan, Dongyi Ma, Ding Li, Shuang Wang, Shixuan Risk model in stage IB1-IIB cervical cancer with positive node after radical hysterectomy |
title | Risk model in stage IB1-IIB cervical cancer with positive node after radical hysterectomy |
title_full | Risk model in stage IB1-IIB cervical cancer with positive node after radical hysterectomy |
title_fullStr | Risk model in stage IB1-IIB cervical cancer with positive node after radical hysterectomy |
title_full_unstemmed | Risk model in stage IB1-IIB cervical cancer with positive node after radical hysterectomy |
title_short | Risk model in stage IB1-IIB cervical cancer with positive node after radical hysterectomy |
title_sort | risk model in stage ib1-iib cervical cancer with positive node after radical hysterectomy |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892859/ https://www.ncbi.nlm.nih.gov/pubmed/27313462 http://dx.doi.org/10.2147/OTT.S94151 |
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