The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy

BACKGROUND: The ability to evaluate the prognosis of hepatocellular carcinoma (HCC) following hepatectomy using biological markers is of great importance. MATERIALS AND METHODS: In this study, we collected samples from 54 patients with HCC after hepatectomy. Immunohistochemistry was used to detect t...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Xu, Zhu, Kelei, Liu, Jinghua, Chen, Jiang, Tang, Jiacheng, Liang, Yuelong, Jin, Renan, Liang, Xiao, Cai, Xiujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892862/
https://www.ncbi.nlm.nih.gov/pubmed/27313467
http://dx.doi.org/10.2147/OTT.S98322
Descripción
Sumario:BACKGROUND: The ability to evaluate the prognosis of hepatocellular carcinoma (HCC) following hepatectomy using biological markers is of great importance. MATERIALS AND METHODS: In this study, we collected samples from 54 patients with HCC after hepatectomy. Immunohistochemistry was used to detect the expression of Sema3C and MFN2 in the HCC samples. RESULTS: Immunohistochemistry results showed that Sema3C and MFN2 co-expression was significantly associated with tumor size. In addition, a significant association between high Sema3C and low MFN2 levels and shorter overall survival was noted, when Sema3C and MFN2 co-expression was analyzed. CONCLUSION: The results suggest that the correlative expression level of Sema3C and MFN2 has a strong value in the prognosis of patients with HCC following hepatectomy.

Ejemplares similares