The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy

BACKGROUND: The ability to evaluate the prognosis of hepatocellular carcinoma (HCC) following hepatectomy using biological markers is of great importance. MATERIALS AND METHODS: In this study, we collected samples from 54 patients with HCC after hepatectomy. Immunohistochemistry was used to detect t...

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Autores principales: Feng, Xu, Zhu, Kelei, Liu, Jinghua, Chen, Jiang, Tang, Jiacheng, Liang, Yuelong, Jin, Renan, Liang, Xiao, Cai, Xiujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892862/
https://www.ncbi.nlm.nih.gov/pubmed/27313467
http://dx.doi.org/10.2147/OTT.S98322
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author Feng, Xu
Zhu, Kelei
Liu, Jinghua
Chen, Jiang
Tang, Jiacheng
Liang, Yuelong
Jin, Renan
Liang, Xiao
Cai, Xiujun
author_facet Feng, Xu
Zhu, Kelei
Liu, Jinghua
Chen, Jiang
Tang, Jiacheng
Liang, Yuelong
Jin, Renan
Liang, Xiao
Cai, Xiujun
author_sort Feng, Xu
collection PubMed
description BACKGROUND: The ability to evaluate the prognosis of hepatocellular carcinoma (HCC) following hepatectomy using biological markers is of great importance. MATERIALS AND METHODS: In this study, we collected samples from 54 patients with HCC after hepatectomy. Immunohistochemistry was used to detect the expression of Sema3C and MFN2 in the HCC samples. RESULTS: Immunohistochemistry results showed that Sema3C and MFN2 co-expression was significantly associated with tumor size. In addition, a significant association between high Sema3C and low MFN2 levels and shorter overall survival was noted, when Sema3C and MFN2 co-expression was analyzed. CONCLUSION: The results suggest that the correlative expression level of Sema3C and MFN2 has a strong value in the prognosis of patients with HCC following hepatectomy.
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spelling pubmed-48928622016-06-16 The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy Feng, Xu Zhu, Kelei Liu, Jinghua Chen, Jiang Tang, Jiacheng Liang, Yuelong Jin, Renan Liang, Xiao Cai, Xiujun Onco Targets Ther Original Research BACKGROUND: The ability to evaluate the prognosis of hepatocellular carcinoma (HCC) following hepatectomy using biological markers is of great importance. MATERIALS AND METHODS: In this study, we collected samples from 54 patients with HCC after hepatectomy. Immunohistochemistry was used to detect the expression of Sema3C and MFN2 in the HCC samples. RESULTS: Immunohistochemistry results showed that Sema3C and MFN2 co-expression was significantly associated with tumor size. In addition, a significant association between high Sema3C and low MFN2 levels and shorter overall survival was noted, when Sema3C and MFN2 co-expression was analyzed. CONCLUSION: The results suggest that the correlative expression level of Sema3C and MFN2 has a strong value in the prognosis of patients with HCC following hepatectomy. Dove Medical Press 2016-05-30 /pmc/articles/PMC4892862/ /pubmed/27313467 http://dx.doi.org/10.2147/OTT.S98322 Text en © 2016 Feng et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Feng, Xu
Zhu, Kelei
Liu, Jinghua
Chen, Jiang
Tang, Jiacheng
Liang, Yuelong
Jin, Renan
Liang, Xiao
Cai, Xiujun
The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy
title The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy
title_full The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy
title_fullStr The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy
title_full_unstemmed The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy
title_short The evaluative value of Sema3C and MFN2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy
title_sort evaluative value of sema3c and mfn2 co-expression detected by immunohistochemistry for prognosis in hepatocellular carcinoma patients after hepatectomy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892862/
https://www.ncbi.nlm.nih.gov/pubmed/27313467
http://dx.doi.org/10.2147/OTT.S98322
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