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Engineering therapeutic antibodies targeting G-protein–coupled receptors
G-protein–coupled receptors (GPCRs) are one of the most attractive therapeutic target classes because of their critical roles in intracellular signaling and their clinical relevance to a variety of diseases, including cancer, infection and inflammation. However, high conformational variability, the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892866/ https://www.ncbi.nlm.nih.gov/pubmed/26846450 http://dx.doi.org/10.1038/emm.2015.105 |