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Post-transcriptional control of the mammalian circadian clock: implications for health and disease
Many aspects of human physiology and behavior display rhythmicity with a period of approximately 24 h. Rhythmic changes are controlled by an endogenous time keeper, the circadian clock, and include sleep-wake cycles, physical and mental performance capability, blood pressure, and body temperature. C...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893061/ https://www.ncbi.nlm.nih.gov/pubmed/27108448 http://dx.doi.org/10.1007/s00424-016-1820-y |
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author | Preußner, Marco Heyd, Florian |
author_facet | Preußner, Marco Heyd, Florian |
author_sort | Preußner, Marco |
collection | PubMed |
description | Many aspects of human physiology and behavior display rhythmicity with a period of approximately 24 h. Rhythmic changes are controlled by an endogenous time keeper, the circadian clock, and include sleep-wake cycles, physical and mental performance capability, blood pressure, and body temperature. Consequently, many diseases, such as metabolic, sleep, autoimmune and mental disorders and cancer, are connected to the circadian rhythm. The development of therapies that take circadian biology into account is thus a promising strategy to improve treatments of diverse disorders, ranging from allergic syndromes to cancer. Circadian alteration of body functions and behavior are, at the molecular level, controlled and mediated by widespread changes in gene expression that happen in anticipation of predictably changing requirements during the day. At the core of the molecular clockwork is a well-studied transcription-translation negative feedback loop. However, evidence is emerging that additional post-transcriptional, RNA-based mechanisms are required to maintain proper clock function. Here, we will discuss recent work implicating regulated mRNA stability, translation and alternative splicing in the control of the mammalian circadian clock, and its role in health and disease. |
format | Online Article Text |
id | pubmed-4893061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-48930612016-06-20 Post-transcriptional control of the mammalian circadian clock: implications for health and disease Preußner, Marco Heyd, Florian Pflugers Arch Invited Review Many aspects of human physiology and behavior display rhythmicity with a period of approximately 24 h. Rhythmic changes are controlled by an endogenous time keeper, the circadian clock, and include sleep-wake cycles, physical and mental performance capability, blood pressure, and body temperature. Consequently, many diseases, such as metabolic, sleep, autoimmune and mental disorders and cancer, are connected to the circadian rhythm. The development of therapies that take circadian biology into account is thus a promising strategy to improve treatments of diverse disorders, ranging from allergic syndromes to cancer. Circadian alteration of body functions and behavior are, at the molecular level, controlled and mediated by widespread changes in gene expression that happen in anticipation of predictably changing requirements during the day. At the core of the molecular clockwork is a well-studied transcription-translation negative feedback loop. However, evidence is emerging that additional post-transcriptional, RNA-based mechanisms are required to maintain proper clock function. Here, we will discuss recent work implicating regulated mRNA stability, translation and alternative splicing in the control of the mammalian circadian clock, and its role in health and disease. Springer Berlin Heidelberg 2016-04-23 2016 /pmc/articles/PMC4893061/ /pubmed/27108448 http://dx.doi.org/10.1007/s00424-016-1820-y Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Invited Review Preußner, Marco Heyd, Florian Post-transcriptional control of the mammalian circadian clock: implications for health and disease |
title | Post-transcriptional control of the mammalian circadian clock: implications for health and disease |
title_full | Post-transcriptional control of the mammalian circadian clock: implications for health and disease |
title_fullStr | Post-transcriptional control of the mammalian circadian clock: implications for health and disease |
title_full_unstemmed | Post-transcriptional control of the mammalian circadian clock: implications for health and disease |
title_short | Post-transcriptional control of the mammalian circadian clock: implications for health and disease |
title_sort | post-transcriptional control of the mammalian circadian clock: implications for health and disease |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893061/ https://www.ncbi.nlm.nih.gov/pubmed/27108448 http://dx.doi.org/10.1007/s00424-016-1820-y |
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