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Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study

OBJECTIVES: Lung exposures including cigarette smoking and silica exposure are associated with the risk of rheumatoid arthritis (RA). We investigated the association between textile dust exposure and the risk of RA in the Malaysian population, with a focus on women who rarely smoke. METHODS: Data fr...

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Autores principales: Too, Chun Lai, Muhamad, Nor Asiah, Ilar, Anna, Padyukov, Leonid, Alfredsson, Lars, Klareskog, Lars, Murad, Shahnaz, Bengtsson, Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893106/
https://www.ncbi.nlm.nih.gov/pubmed/26681695
http://dx.doi.org/10.1136/annrheumdis-2015-208278
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author Too, Chun Lai
Muhamad, Nor Asiah
Ilar, Anna
Padyukov, Leonid
Alfredsson, Lars
Klareskog, Lars
Murad, Shahnaz
Bengtsson, Camilla
author_facet Too, Chun Lai
Muhamad, Nor Asiah
Ilar, Anna
Padyukov, Leonid
Alfredsson, Lars
Klareskog, Lars
Murad, Shahnaz
Bengtsson, Camilla
author_sort Too, Chun Lai
collection PubMed
description OBJECTIVES: Lung exposures including cigarette smoking and silica exposure are associated with the risk of rheumatoid arthritis (RA). We investigated the association between textile dust exposure and the risk of RA in the Malaysian population, with a focus on women who rarely smoke. METHODS: Data from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis population-based case–control study involving 910 female early RA cases and 910 female age-matched controls were analysed. Self-reported information on ever/never occupationally exposed to textile dust was used to estimate the risk of developing anti-citrullinated protein antibody (ACPA)-positive and ACPA-negative RA. Interaction between textile dust and the human leucocyte antigen DR β-1 (HLA-DRB1) shared epitope (SE) was evaluated by calculating the attributable proportion due to interaction (AP), with 95% CI. RESULTS: Occupational exposure to textile dust was significantly associated with an increased risk of developing RA in the Malaysian female population (OR 2.8, 95% CI 1.6 to 5.2). The association between occupational exposure to textile dust and risk of RA was uniformly observed for the ACPA-positive RA (OR 2.5, 95% CI 1.3 to 4.8) and ACPA-negative RA (OR 3.5, 95% CI 1.7 to 7.0) subsets, respectively. We observed a significant interaction between exposure to occupational textile dust and HLA-DRB1 SE alleles regarding the risk of ACPA-positive RA (OR for double exposed: 39.1, 95% CI 5.1 to 297.5; AP: 0.8, 95% CI 0.5 to 1.2). CONCLUSIONS: This is the first study demonstrating that textile dust exposure is associated with an increased risk for RA. In addition, a gene–environment interaction between HLA-DRB1 SE and textile dust exposure provides a high risk for ACPA-positive RA.
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spelling pubmed-48931062016-06-09 Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study Too, Chun Lai Muhamad, Nor Asiah Ilar, Anna Padyukov, Leonid Alfredsson, Lars Klareskog, Lars Murad, Shahnaz Bengtsson, Camilla Ann Rheum Dis Clinical and Epidemiological Research OBJECTIVES: Lung exposures including cigarette smoking and silica exposure are associated with the risk of rheumatoid arthritis (RA). We investigated the association between textile dust exposure and the risk of RA in the Malaysian population, with a focus on women who rarely smoke. METHODS: Data from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis population-based case–control study involving 910 female early RA cases and 910 female age-matched controls were analysed. Self-reported information on ever/never occupationally exposed to textile dust was used to estimate the risk of developing anti-citrullinated protein antibody (ACPA)-positive and ACPA-negative RA. Interaction between textile dust and the human leucocyte antigen DR β-1 (HLA-DRB1) shared epitope (SE) was evaluated by calculating the attributable proportion due to interaction (AP), with 95% CI. RESULTS: Occupational exposure to textile dust was significantly associated with an increased risk of developing RA in the Malaysian female population (OR 2.8, 95% CI 1.6 to 5.2). The association between occupational exposure to textile dust and risk of RA was uniformly observed for the ACPA-positive RA (OR 2.5, 95% CI 1.3 to 4.8) and ACPA-negative RA (OR 3.5, 95% CI 1.7 to 7.0) subsets, respectively. We observed a significant interaction between exposure to occupational textile dust and HLA-DRB1 SE alleles regarding the risk of ACPA-positive RA (OR for double exposed: 39.1, 95% CI 5.1 to 297.5; AP: 0.8, 95% CI 0.5 to 1.2). CONCLUSIONS: This is the first study demonstrating that textile dust exposure is associated with an increased risk for RA. In addition, a gene–environment interaction between HLA-DRB1 SE and textile dust exposure provides a high risk for ACPA-positive RA. BMJ Publishing Group 2016-06 2015-12-17 /pmc/articles/PMC4893106/ /pubmed/26681695 http://dx.doi.org/10.1136/annrheumdis-2015-208278 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Clinical and Epidemiological Research
Too, Chun Lai
Muhamad, Nor Asiah
Ilar, Anna
Padyukov, Leonid
Alfredsson, Lars
Klareskog, Lars
Murad, Shahnaz
Bengtsson, Camilla
Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study
title Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study
title_full Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study
title_fullStr Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study
title_full_unstemmed Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study
title_short Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study
title_sort occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a malaysian population-based case–control study
topic Clinical and Epidemiological Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893106/
https://www.ncbi.nlm.nih.gov/pubmed/26681695
http://dx.doi.org/10.1136/annrheumdis-2015-208278
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