Cargando…

TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice

OBJECTIVE: The gut microbiota modulates host susceptibility to intestinal inflammation, but the cell types and the signalling pathways orchestrating this bacterial regulation of intestinal homeostasis remain poorly understood. Here, we investigated the function of intestinal epithelial toll-like rec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vlantis, Katerina, Polykratis, Apostolos, Welz, Patrick-Simon, van Loo, Geert, Pasparakis, Manolis, Wullaert, Andy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Experimental Colitis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893119/ https://www.ncbi.nlm.nih.gov/pubmed/25761602 http://dx.doi.org/10.1136/gutjnl-2014-308323

Ejemplares similares

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions
por: Vlantis, Katerina, et al.
Publicado: (2016)

Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice
por: Sedhom, Mamdouh A K, et al.
Publicado: (2013)

Endoscopic tri-modal imaging for surveillance in ulcerative colitis: randomised comparison of high-resolution endoscopy and autofluorescence imaging for neoplasia detection; and evaluation of narrow-band imaging for classification of lesions
por: van den Broek, F J C, et al.
Publicado: (2008)

Correction: Bacteria Regulate Intestinal Epithelial Cell Differentiation Factors Both In Vitro and In Vivo
por: Becker, Svetlana, et al.
Publicado: (2013)

Tofacitinib for ulcerative colitis: results of the prospective Dutch Initiative on Crohn and Colitis (ICC) registry
por: Biemans, Vince B. C., et al.
Publicado: (2020)

Effectiveness and safety of tofacitinib for ulcerative colitis: two‐year results of the ICC Registry
por: Straatmijer, Tessa, et al.
Publicado: (2022)

Persistence of treatment in patients with ulcerative colitis who responded to tofacitinib therapy: data from the open‐label, long‐term extension study, OCTAVE open
por: Panaccione, Remo, et al.
Publicado: (2022)

Intestinal ultrasound detects an increased diameter and submucosal layer thickness in the appendix of patients with ulcerative colitis compared to healthy controls – a prospective cohort study
por: Reijntjes, Maud A., et al.
Publicado: (2022)

Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
por: Koliaraki, Vasiliki, et al.
Publicado: (2019)

The effectiveness and safety of infliximab compared with biosimilar CT‐P13, in 3112 patients with ulcerative colitis
por: Meyer, Antoine, et al.
Publicado: (2019)

Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes
por: Androulidaki, Ariadne, et al.
Publicado: (2018)

Bacteria Regulate Intestinal Epithelial Cell Differentiation Factors Both In Vitro and In Vivo
por: Becker, Svetlana, et al.
Publicado: (2013)

Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE(−/−) mice
por: Imai, Takashi, et al.
Publicado: (2022)

The taxonomic composition of the donor intestinal microbiota is a major factor influencing the efficacy of faecal microbiota transplantation in therapy refractory ulcerative colitis
por: Kump, P., et al.
Publicado: (2017)

Vedolizumab exposure levels and clinical outcomes in ulcerative colitis: determining the potential for dose optimisation
por: Osterman, Mark T., et al.
Publicado: (2019)

Safety and efficacy of tofacitinib for treatment of ulcerative colitis: final analysis of OCTAVE Open, an open‐label, long‐term extension study with up to 7.0 years of treatment
por: Sandborn, William J., et al.
Publicado: (2021)

Worldwide post‐marketing safety surveillance experience with tofacitinib in ulcerative colitis
por: Rubin, David T., et al.
Publicado: (2021)

Nationwide improvement in outcomes of emergency admission for ulcerative colitis in England, 2005‐2013
por: Shawihdi, Mustafa, et al.
Publicado: (2019)

IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer
por: Koliaraki, Vasiliki, et al.
Publicado: (2015)

El Tor Biotype Vibrio cholerae Activates the Caspase-11-Independent Canonical Nlrp3 and Pyrin Inflammasomes
por: Mamantopoulos, Michail, et al.
Publicado: (2019)

Nucleic Acid Induced Interferon and Inflammasome Responses in Regulating Host Defense to Gastrointestinal Viruses
por: Dubois, Hanne, et al.
Publicado: (2019)

TRIP6 promotes inflammatory damage via the activation of TRAF6 signaling in a murine model of DSS-induced colitis
por: Yang, Yun, et al.
Publicado: (2022)

Intestinal Epithelial AMPK Deficiency Causes Delayed Colonic Epithelial Repair in DSS-Induced Colitis
por: Olivier, Séverine, et al.
Publicado: (2022)

Gasdermin D independent canonical inflammasome responses cooperate with caspase-8 to establish host defense against gastrointestinal Citrobacter rodentium infection
por: Eeckhout, Elien, et al.
Publicado: (2023)

Mucosal 5‐aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
por: Olaisen, Maya, et al.
Publicado: (2019)

Generalized immune activation as a direct result of activated CD4(+ )T cell killing
por: Marques, Rute, et al.
Publicado: (2009)

Fish Sidestream-Derived Protein Hydrolysates Suppress DSS-Induced Colitis by Modulating Intestinal Inflammation in Mice
por: Daskalaki, Maria G., et al.
Publicado: (2021)

Epithelial IKKα licenses ILC3s to defend the intestinal barrier
por: Eftychi, Christina, et al.
Publicado: (2015)

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis
por: Vereecke, Lars, et al.
Publicado: (2010)

Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin
por: Chelakkot, Chaithanya, et al.
Publicado: (2017)

TLR2 and interleukin-10 are involved in Bacteroides fragilis-mediated prevention of DSS-induced colitis in gnotobiotic mice
por: Chang, Yi-Chih, et al.
Publicado: (2017)

Nigella A ameliorates inflammation and intestinal flora imbalance in DSS induced colitis mice
por: Hu, Xingjiang, et al.
Publicado: (2020)

Artemisinin Alleviates Intestinal Inflammation and Metabolic Disturbance in Ulcerative Colitis Rats Induced by DSS
por: Jia, Xuemei, et al.
Publicado: (2022)

Carnosol Maintains Intestinal Barrier Function and Mucosal Immune Homeostasis in DSS-Induced Colitis
por: Xu, Xiang, et al.
Publicado: (2022)

Crocetin Prolongs Recovery Period of DSS-Induced Colitis via Altering Intestinal Microbiome and Increasing Intestinal Permeability
por: Feng, Peishi, et al.
Publicado: (2022)

The Role of CXCR3 in DSS-Induced Colitis
por: Chami, Belal, et al.
Publicado: (2014)

Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis
por: He, Xuexiu, et al.
Publicado: (2016)

MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota
por: Li, Nengneng, et al.
Publicado: (2023)

Jatrorrhizine Alleviates DSS-Induced Ulcerative Colitis by Regulating the Intestinal Barrier Function and Inhibiting TLR4/MyD88/NF-κB Signaling Pathway
por: Niu, Shengqi, et al.
Publicado: (2022)

Bifidobacteria Prevent Tunicamycin-Induced Endoplasmic Reticulum Stress and Subsequent Barrier Disruption in Human Intestinal Epithelial Caco-2 Monolayers
por: Akiyama, Takuya, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_b71ca73sas6ib56479c3tc8nqm