The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

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The HECT domain E3 ligase HACE1 has been identified as a tumor suppressor in multiple cancers. Here, we report that HACE1 is a central gatekeeper of TNFR1-induced cell fate. Genetic inactivation of HACE1 inhibits TNF-stimulated NF-κB activation and TNFR1-NF-κB-dependent pathogen clearance in vivo. M...

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Detalles Bibliográficos
Autores principales: Tortola, Luigi, Nitsch, Roberto, Bertrand, Mathieu J.M., Kogler, Melanie, Redouane, Younes, Kozieradzki, Ivona, Uribesalgo, Iris, Fennell, Lilian M., Daugaard, Mads, Klug, Helene, Wirnsberger, Gerald, Wimmer, Reiner, Perlot, Thomas, Sarao, Renu, Rao, Shuan, Hanada, Toshikatsu, Takahashi, Nozomi, Kernbauer, Elisabeth, Demiröz, Duygu, Superti-Furga, Giulio, Decker, Thomas, Pichler, Andrea, Ikeda, Fumiyo, Kroemer, Guido, Vandenabeele, Peter, Sorensen, Poul H., Penninger, Josef M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893156/
https://www.ncbi.nlm.nih.gov/pubmed/27160902
http://dx.doi.org/10.1016/j.celrep.2016.04.032
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