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Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations
Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polya...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893575/ https://www.ncbi.nlm.nih.gov/pubmed/27313866 http://dx.doi.org/10.1155/2016/2647264 |
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author | Budai-Szűcs, Mária Horvát, Gabriella Szilágyi, Barnabás Áron Gyarmati, Benjámin Szilágyi, András Berkó, Szilvia Szabó-Révész, Piroska Sandri, Giuseppina Bonferoni, Maria Cristina Caramella, Carla Soós, Judit Facskó, Andrea Csányi, Erzsébet |
author_facet | Budai-Szűcs, Mária Horvát, Gabriella Szilágyi, Barnabás Áron Gyarmati, Benjámin Szilágyi, András Berkó, Szilvia Szabó-Révész, Piroska Sandri, Giuseppina Bonferoni, Maria Cristina Caramella, Carla Soós, Judit Facskó, Andrea Csányi, Erzsébet |
author_sort | Budai-Szűcs, Mária |
collection | PubMed |
description | Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N′,N′-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups. The solution of the polymer is therefore able to mimic the physiological properties of the mucins and it can interact with the mucus layer via disulphide bond formation. The resultant mucoadhesion provides a prolonged residence time and ensures protective effect for the corneal/conjunctival epithelium. ThioPASP-DME also has an antioxidant effect due to the presence of the thiol groups. The applicability of ThioPASP-DME as a potential excipient in eye drops was determined by means of ocular compatibility tests and through examinations of the interactions with the mucosal surface. The results indicate that ThioPASP-DME can serve as a potential eye drop excipient for the therapy of dry eye disease. |
format | Online Article Text |
id | pubmed-4893575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48935752016-06-16 Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations Budai-Szűcs, Mária Horvát, Gabriella Szilágyi, Barnabás Áron Gyarmati, Benjámin Szilágyi, András Berkó, Szilvia Szabó-Révész, Piroska Sandri, Giuseppina Bonferoni, Maria Cristina Caramella, Carla Soós, Judit Facskó, Andrea Csányi, Erzsébet J Ophthalmol Research Article Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N′,N′-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups. The solution of the polymer is therefore able to mimic the physiological properties of the mucins and it can interact with the mucus layer via disulphide bond formation. The resultant mucoadhesion provides a prolonged residence time and ensures protective effect for the corneal/conjunctival epithelium. ThioPASP-DME also has an antioxidant effect due to the presence of the thiol groups. The applicability of ThioPASP-DME as a potential excipient in eye drops was determined by means of ocular compatibility tests and through examinations of the interactions with the mucosal surface. The results indicate that ThioPASP-DME can serve as a potential eye drop excipient for the therapy of dry eye disease. Hindawi Publishing Corporation 2016 2016-05-23 /pmc/articles/PMC4893575/ /pubmed/27313866 http://dx.doi.org/10.1155/2016/2647264 Text en Copyright © 2016 Mária Budai-Szűcs et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Budai-Szűcs, Mária Horvát, Gabriella Szilágyi, Barnabás Áron Gyarmati, Benjámin Szilágyi, András Berkó, Szilvia Szabó-Révész, Piroska Sandri, Giuseppina Bonferoni, Maria Cristina Caramella, Carla Soós, Judit Facskó, Andrea Csányi, Erzsébet Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations |
title | Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations |
title_full | Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations |
title_fullStr | Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations |
title_full_unstemmed | Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations |
title_short | Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations |
title_sort | cationic thiolated poly(aspartamide) polymer as a potential excipient for artificial tear formulations |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893575/ https://www.ncbi.nlm.nih.gov/pubmed/27313866 http://dx.doi.org/10.1155/2016/2647264 |
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