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Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations

Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polya...

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Autores principales: Budai-Szűcs, Mária, Horvát, Gabriella, Szilágyi, Barnabás Áron, Gyarmati, Benjámin, Szilágyi, András, Berkó, Szilvia, Szabó-Révész, Piroska, Sandri, Giuseppina, Bonferoni, Maria Cristina, Caramella, Carla, Soós, Judit, Facskó, Andrea, Csányi, Erzsébet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893575/
https://www.ncbi.nlm.nih.gov/pubmed/27313866
http://dx.doi.org/10.1155/2016/2647264
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author Budai-Szűcs, Mária
Horvát, Gabriella
Szilágyi, Barnabás Áron
Gyarmati, Benjámin
Szilágyi, András
Berkó, Szilvia
Szabó-Révész, Piroska
Sandri, Giuseppina
Bonferoni, Maria Cristina
Caramella, Carla
Soós, Judit
Facskó, Andrea
Csányi, Erzsébet
author_facet Budai-Szűcs, Mária
Horvát, Gabriella
Szilágyi, Barnabás Áron
Gyarmati, Benjámin
Szilágyi, András
Berkó, Szilvia
Szabó-Révész, Piroska
Sandri, Giuseppina
Bonferoni, Maria Cristina
Caramella, Carla
Soós, Judit
Facskó, Andrea
Csányi, Erzsébet
author_sort Budai-Szűcs, Mária
collection PubMed
description Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N′,N′-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups. The solution of the polymer is therefore able to mimic the physiological properties of the mucins and it can interact with the mucus layer via disulphide bond formation. The resultant mucoadhesion provides a prolonged residence time and ensures protective effect for the corneal/conjunctival epithelium. ThioPASP-DME also has an antioxidant effect due to the presence of the thiol groups. The applicability of ThioPASP-DME as a potential excipient in eye drops was determined by means of ocular compatibility tests and through examinations of the interactions with the mucosal surface. The results indicate that ThioPASP-DME can serve as a potential eye drop excipient for the therapy of dry eye disease.
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spelling pubmed-48935752016-06-16 Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations Budai-Szűcs, Mária Horvát, Gabriella Szilágyi, Barnabás Áron Gyarmati, Benjámin Szilágyi, András Berkó, Szilvia Szabó-Révész, Piroska Sandri, Giuseppina Bonferoni, Maria Cristina Caramella, Carla Soós, Judit Facskó, Andrea Csányi, Erzsébet J Ophthalmol Research Article Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in the quality of life. The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear film. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N′,N′-dimethylaminoethyl)aspartamide)] (ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of ThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups. The solution of the polymer is therefore able to mimic the physiological properties of the mucins and it can interact with the mucus layer via disulphide bond formation. The resultant mucoadhesion provides a prolonged residence time and ensures protective effect for the corneal/conjunctival epithelium. ThioPASP-DME also has an antioxidant effect due to the presence of the thiol groups. The applicability of ThioPASP-DME as a potential excipient in eye drops was determined by means of ocular compatibility tests and through examinations of the interactions with the mucosal surface. The results indicate that ThioPASP-DME can serve as a potential eye drop excipient for the therapy of dry eye disease. Hindawi Publishing Corporation 2016 2016-05-23 /pmc/articles/PMC4893575/ /pubmed/27313866 http://dx.doi.org/10.1155/2016/2647264 Text en Copyright © 2016 Mária Budai-Szűcs et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Budai-Szűcs, Mária
Horvát, Gabriella
Szilágyi, Barnabás Áron
Gyarmati, Benjámin
Szilágyi, András
Berkó, Szilvia
Szabó-Révész, Piroska
Sandri, Giuseppina
Bonferoni, Maria Cristina
Caramella, Carla
Soós, Judit
Facskó, Andrea
Csányi, Erzsébet
Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations
title Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations
title_full Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations
title_fullStr Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations
title_full_unstemmed Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations
title_short Cationic Thiolated Poly(aspartamide) Polymer as a Potential Excipient for Artificial Tear Formulations
title_sort cationic thiolated poly(aspartamide) polymer as a potential excipient for artificial tear formulations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893575/
https://www.ncbi.nlm.nih.gov/pubmed/27313866
http://dx.doi.org/10.1155/2016/2647264
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