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Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function
In humans, more than 200 missense mutations have been identified in the ACTA1 gene. The exact molecular mechanisms by which, these particular mutations become toxic and lead to muscle weakness and myopathies remain obscure. To address this, here, we performed a molecular dynamics simulation, and we...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Pub. Co
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894126/ https://www.ncbi.nlm.nih.gov/pubmed/27112274 http://dx.doi.org/10.1016/j.bbadis.2016.04.013 |