Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib

BACKGROUND: Sorafenib, a kinase inhibitor active against various solid tumours, induces oxidative stress and ferroptosis, a new form of oxidative necrosis, in some cancer cells. Clinically-applicable biomarkers that reflect the impact of sorafenib on the redox metabolism of cancer cells are lacking....

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Detalles Bibliográficos
Autores principales: Houessinon, Aline, François, Catherine, Sauzay, Chloé, Louandre, Christophe, Mongelard, Gaelle, Godin, Corinne, Bodeau, Sandra, Takahashi, Shinichiro, Saidak, Zuzana, Gutierrez, Laurent, Régimbeau, Jean-Marc, Barget, Nathalie, Barbare, Jean-Claude, Ganne, Nathalie, Chauffert, Bruno, Coriat, Romain, Galmiche, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894370/
https://www.ncbi.nlm.nih.gov/pubmed/27184800
http://dx.doi.org/10.1186/s12943-016-0526-2

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