Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated secretion

BACKGROUND: Somatic calreticulin (CALR), Janus kinase 2 (JAK2), and thrombopoietin receptor (MPL) mutations essentially show mutual exclusion in myeloproliferative neoplasms (MPN), suggesting that they activate common oncogenic pathways. Recent data have shown that MPL function is essential for CALR...

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Detalles Bibliográficos
Autores principales: Han, Lijuan, Schubert, Claudia, Köhler, Johanna, Schemionek, Mirle, Isfort, Susanne, Brümmendorf, Tim H., Koschmieder, Steffen, Chatain, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894373/
https://www.ncbi.nlm.nih.gov/pubmed/27177927
http://dx.doi.org/10.1186/s13045-016-0275-0

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