Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells

We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This ra...

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Detalles Bibliográficos
Autores principales: Suarez, Allison, Ueno, Tasuku, Huebner, Robert, McCaffery, J. Michael, Inoue, Takanari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894391/
https://www.ncbi.nlm.nih.gov/pubmed/24796975
http://dx.doi.org/10.1038/srep04693
Descripción
Sumario:We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles.

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