Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells

We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This ra...

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Detalles Bibliográficos
Autores principales: Suarez, Allison, Ueno, Tasuku, Huebner, Robert, McCaffery, J. Michael, Inoue, Takanari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894391/
https://www.ncbi.nlm.nih.gov/pubmed/24796975
http://dx.doi.org/10.1038/srep04693
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author Suarez, Allison
Ueno, Tasuku
Huebner, Robert
McCaffery, J. Michael
Inoue, Takanari
author_facet Suarez, Allison
Ueno, Tasuku
Huebner, Robert
McCaffery, J. Michael
Inoue, Takanari
author_sort Suarez, Allison
collection PubMed
description We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles.
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spelling pubmed-48943912016-06-10 Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells Suarez, Allison Ueno, Tasuku Huebner, Robert McCaffery, J. Michael Inoue, Takanari Sci Rep Article We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles. Nature Publishing Group 2014-05-06 /pmc/articles/PMC4894391/ /pubmed/24796975 http://dx.doi.org/10.1038/srep04693 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Suarez, Allison
Ueno, Tasuku
Huebner, Robert
McCaffery, J. Michael
Inoue, Takanari
Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells
title Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells
title_full Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells
title_fullStr Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells
title_full_unstemmed Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells
title_short Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells
title_sort bin/amphiphysin/rvs (bar) family members bend membranes in cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894391/
https://www.ncbi.nlm.nih.gov/pubmed/24796975
http://dx.doi.org/10.1038/srep04693
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