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Efficient genetic manipulation of the NOD-Rag1-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology

Humanized mouse models have become increasingly important and widely used in modeling human diseases in biomedical research. Immunodeficient mice such as NOD-Rag1-/-IL2RgammaC-null (NRG) or NOD-SCID-IL2RgammaC-null (NSG) mice are critical for efficient engraftment of human cells or tissues. However,...

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Detalles Bibliográficos
Autores principales:	Li, Feng, Cowley, Dale O., Banner, Debra, Holle, Eric, Zhang, Liguo, Su, Lishan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894429/ https://www.ncbi.nlm.nih.gov/pubmed/24936832 http://dx.doi.org/10.1038/srep05290

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