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Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice

Intervertebral disc (IVD) degeneration is a common degenerative disease, yet much is unknown about the mechanisms during its pathogenesis. Herein we investigated whether progranulin (PGRN), a chondroprotective growth factor, is associated with IVD degeneration. PGRN was detectable in both human and...

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Detalles Bibliográficos
Autores principales:	Zhao, Yun-peng, Tian, Qing-yun, Liu, Ben, Cuellar, Jason, Richbourgh, Brendon, Jia, Tang-hong, Liu, Chuan-ju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894449/ https://www.ncbi.nlm.nih.gov/pubmed/25777988 http://dx.doi.org/10.1038/srep09102

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