Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

Pancreatic ductal adenocarcinoma (PDAC) is a devastating metastatic disease for which better therapies are urgently needed. Macrophages enhance metastasis in many cancer types, however, the role of macrophages in PDAC liver metastasis remains poorly understood. Here we found that PDAC liver metastas...

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Detalles Bibliográficos
Autores principales: Nielsen, Sebastian R, Quaranta, Valeria, Linford, Andrea, Emeagi, Perpetua, Rainer, Carolyn, Santos, Almudena, Ireland, Lucy, Sakai, Takao, Sakai, Keiko, Kim, Yong-Sam, Engle, Dannielle, Campbell, Fiona, Palmer, Daniel, Ko, Jeong Heon, Tuveson, David A., Hirsch, Emilio, Mielgo, Ainhoa, Schmid, Michael C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894551/
https://www.ncbi.nlm.nih.gov/pubmed/27088855
http://dx.doi.org/10.1038/ncb3340

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