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Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory
Hostility has been associated with higher basal levels of inflammation. The present study evaluated the association of hostility with acute stress-induced changes in inflammatory activity. One hundred and ninety-nine healthy men and women, aged 19–64 years, were exposed to a stress protocol involvin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894569/ https://www.ncbi.nlm.nih.gov/pubmed/27270459 http://dx.doi.org/10.1371/journal.pone.0156329 |
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author | Girard, Dominique Tardif, Jean-Claude Boisclair Demarble, Julie D’Antono, Bianca |
author_facet | Girard, Dominique Tardif, Jean-Claude Boisclair Demarble, Julie D’Antono, Bianca |
author_sort | Girard, Dominique |
collection | PubMed |
description | Hostility has been associated with higher basal levels of inflammation. The present study evaluated the association of hostility with acute stress-induced changes in inflammatory activity. One hundred and ninety-nine healthy men and women, aged 19–64 years, were exposed to a stress protocol involving four interpersonal stressors. Participants completed the Cook-Medley Hostility questionnaire and provided two blood samples for the measurement of inflammatory biomarkers (CRP, Il-6, MPO, TNF-α, MCP-1, Il-8, Il-10, and Il-18), prior to and following exposure to a standardized stress protocol. In univariate analyses, hostility was associated with significantly higher TNF-α, but lower Il-8 and Il-18 values post-stress, though only Il-8 remained significant after controlling for baseline differences. In multivariate analyses, a significant Age by Hostility interaction emerged for Il-6, while sex moderated the relation between hostility and Il-10 reactivity. Following stress, hostility was associated with greater pro-inflammatory Il-6 activity among younger individuals and to decreased anti-inflammatory Il-10 activity in women. Future research is needed to replicate these findings and to evaluate their implication for disease. |
format | Online Article Text |
id | pubmed-4894569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-48945692016-06-23 Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory Girard, Dominique Tardif, Jean-Claude Boisclair Demarble, Julie D’Antono, Bianca PLoS One Research Article Hostility has been associated with higher basal levels of inflammation. The present study evaluated the association of hostility with acute stress-induced changes in inflammatory activity. One hundred and ninety-nine healthy men and women, aged 19–64 years, were exposed to a stress protocol involving four interpersonal stressors. Participants completed the Cook-Medley Hostility questionnaire and provided two blood samples for the measurement of inflammatory biomarkers (CRP, Il-6, MPO, TNF-α, MCP-1, Il-8, Il-10, and Il-18), prior to and following exposure to a standardized stress protocol. In univariate analyses, hostility was associated with significantly higher TNF-α, but lower Il-8 and Il-18 values post-stress, though only Il-8 remained significant after controlling for baseline differences. In multivariate analyses, a significant Age by Hostility interaction emerged for Il-6, while sex moderated the relation between hostility and Il-10 reactivity. Following stress, hostility was associated with greater pro-inflammatory Il-6 activity among younger individuals and to decreased anti-inflammatory Il-10 activity in women. Future research is needed to replicate these findings and to evaluate their implication for disease. Public Library of Science 2016-06-06 /pmc/articles/PMC4894569/ /pubmed/27270459 http://dx.doi.org/10.1371/journal.pone.0156329 Text en © 2016 Girard et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Girard, Dominique Tardif, Jean-Claude Boisclair Demarble, Julie D’Antono, Bianca Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory |
title | Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory |
title_full | Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory |
title_fullStr | Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory |
title_full_unstemmed | Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory |
title_short | Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory |
title_sort | trait hostility and acute inflammatory responses to stress in the laboratory |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894569/ https://www.ncbi.nlm.nih.gov/pubmed/27270459 http://dx.doi.org/10.1371/journal.pone.0156329 |
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