Cargando…

Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory

Hostility has been associated with higher basal levels of inflammation. The present study evaluated the association of hostility with acute stress-induced changes in inflammatory activity. One hundred and ninety-nine healthy men and women, aged 19–64 years, were exposed to a stress protocol involvin...

Descripción completa

Detalles Bibliográficos
Autores principales: Girard, Dominique, Tardif, Jean-Claude, Boisclair Demarble, Julie, D’Antono, Bianca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894569/
https://www.ncbi.nlm.nih.gov/pubmed/27270459
http://dx.doi.org/10.1371/journal.pone.0156329
_version_ 1782435687997374464
author Girard, Dominique
Tardif, Jean-Claude
Boisclair Demarble, Julie
D’Antono, Bianca
author_facet Girard, Dominique
Tardif, Jean-Claude
Boisclair Demarble, Julie
D’Antono, Bianca
author_sort Girard, Dominique
collection PubMed
description Hostility has been associated with higher basal levels of inflammation. The present study evaluated the association of hostility with acute stress-induced changes in inflammatory activity. One hundred and ninety-nine healthy men and women, aged 19–64 years, were exposed to a stress protocol involving four interpersonal stressors. Participants completed the Cook-Medley Hostility questionnaire and provided two blood samples for the measurement of inflammatory biomarkers (CRP, Il-6, MPO, TNF-α, MCP-1, Il-8, Il-10, and Il-18), prior to and following exposure to a standardized stress protocol. In univariate analyses, hostility was associated with significantly higher TNF-α, but lower Il-8 and Il-18 values post-stress, though only Il-8 remained significant after controlling for baseline differences. In multivariate analyses, a significant Age by Hostility interaction emerged for Il-6, while sex moderated the relation between hostility and Il-10 reactivity. Following stress, hostility was associated with greater pro-inflammatory Il-6 activity among younger individuals and to decreased anti-inflammatory Il-10 activity in women. Future research is needed to replicate these findings and to evaluate their implication for disease.
format Online
Article
Text
id pubmed-4894569
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-48945692016-06-23 Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory Girard, Dominique Tardif, Jean-Claude Boisclair Demarble, Julie D’Antono, Bianca PLoS One Research Article Hostility has been associated with higher basal levels of inflammation. The present study evaluated the association of hostility with acute stress-induced changes in inflammatory activity. One hundred and ninety-nine healthy men and women, aged 19–64 years, were exposed to a stress protocol involving four interpersonal stressors. Participants completed the Cook-Medley Hostility questionnaire and provided two blood samples for the measurement of inflammatory biomarkers (CRP, Il-6, MPO, TNF-α, MCP-1, Il-8, Il-10, and Il-18), prior to and following exposure to a standardized stress protocol. In univariate analyses, hostility was associated with significantly higher TNF-α, but lower Il-8 and Il-18 values post-stress, though only Il-8 remained significant after controlling for baseline differences. In multivariate analyses, a significant Age by Hostility interaction emerged for Il-6, while sex moderated the relation between hostility and Il-10 reactivity. Following stress, hostility was associated with greater pro-inflammatory Il-6 activity among younger individuals and to decreased anti-inflammatory Il-10 activity in women. Future research is needed to replicate these findings and to evaluate their implication for disease. Public Library of Science 2016-06-06 /pmc/articles/PMC4894569/ /pubmed/27270459 http://dx.doi.org/10.1371/journal.pone.0156329 Text en © 2016 Girard et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Girard, Dominique
Tardif, Jean-Claude
Boisclair Demarble, Julie
D’Antono, Bianca
Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory
title Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory
title_full Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory
title_fullStr Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory
title_full_unstemmed Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory
title_short Trait Hostility and Acute Inflammatory Responses to Stress in the Laboratory
title_sort trait hostility and acute inflammatory responses to stress in the laboratory
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894569/
https://www.ncbi.nlm.nih.gov/pubmed/27270459
http://dx.doi.org/10.1371/journal.pone.0156329
work_keys_str_mv AT girarddominique traithostilityandacuteinflammatoryresponsestostressinthelaboratory
AT tardifjeanclaude traithostilityandacuteinflammatoryresponsestostressinthelaboratory
AT boisclairdemarblejulie traithostilityandacuteinflammatoryresponsestostressinthelaboratory
AT dantonobianca traithostilityandacuteinflammatoryresponsestostressinthelaboratory