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Facteurs prédictifs de l’échec du Traitement Préventif Intermittent du paludisme à la sulfadoxine – pyriméthamine (TPIp-SP) dans une population de femmes enceintes à Yaoundé
INTRODUCTION: Intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) is recommended for malaria prevention during pregnancy. We investigated factors associated with the failure of this strategy. METHODS: We conducted a case-control study in two health care facilities in Yaounde,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The African Field Epidemiology Network
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894739/ https://www.ncbi.nlm.nih.gov/pubmed/27303570 http://dx.doi.org/10.11604/pamj.2016.23.152.7936 |
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author | Essiben, Félix Foumane, Pascal de Nguefack, Marcelle Aurelie Tsafack Eko, Filbert Eko Njotang, Philip Nana Enow, Robinson Mbu Mboudou, Emile Telesphore |
author_facet | Essiben, Félix Foumane, Pascal de Nguefack, Marcelle Aurelie Tsafack Eko, Filbert Eko Njotang, Philip Nana Enow, Robinson Mbu Mboudou, Emile Telesphore |
author_sort | Essiben, Félix |
collection | PubMed |
description | INTRODUCTION: Intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) is recommended for malaria prevention during pregnancy. We investigated factors associated with the failure of this strategy. METHODS: We conducted a case-control study in two health care facilities in Yaounde, from 1 May 2014 to 30 April 2015. Pregnant women treated with IPTp-SP, hospitalized for malaria and having a positive Rapid Diagnostic Test (RDT) result (case-subjects) were compared to pregnant women treated with IPTp-SP having a negative RDT result (control-subjects). Epi Info 7 software and SPSS 18.0 software were used with P< 0.05 as significance threshold. RESULTS: We recruited 234 subjects, 109 (46.6%) case-subjects and 125 control-subjects (53.4%). The associated factors found were: prematurity (P=0.03; OR=1.15; IC= 0.32 – 4.10), the non-use of LLIN (P=0.006; OR= 2.31; IC= 1.26 – 4.25), a history of hospitalization for malaria (P=0.007; OR= 2.19; IC= 1.23 – 3.89), IPTp-SP administration after 28 gestational weeks (P=0.001, OR= 3.55; IC= 1.7 – 7.61). After logistic regression, prematurity (P=0.024; OR=2.01; IC=1.1-3.7) and a history of hospitalization for malaria (P=0.001; OR=2.83; IC=1.50-5.4) remained associated with IPTp-SP failure. CONCLUSION: A history of hospitalization for malaria and prematurity are independent predictor of IPTp-SP failure. |
format | Online Article Text |
id | pubmed-4894739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The African Field Epidemiology Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-48947392016-06-14 Facteurs prédictifs de l’échec du Traitement Préventif Intermittent du paludisme à la sulfadoxine – pyriméthamine (TPIp-SP) dans une population de femmes enceintes à Yaoundé Essiben, Félix Foumane, Pascal de Nguefack, Marcelle Aurelie Tsafack Eko, Filbert Eko Njotang, Philip Nana Enow, Robinson Mbu Mboudou, Emile Telesphore Pan Afr Med J Research INTRODUCTION: Intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) is recommended for malaria prevention during pregnancy. We investigated factors associated with the failure of this strategy. METHODS: We conducted a case-control study in two health care facilities in Yaounde, from 1 May 2014 to 30 April 2015. Pregnant women treated with IPTp-SP, hospitalized for malaria and having a positive Rapid Diagnostic Test (RDT) result (case-subjects) were compared to pregnant women treated with IPTp-SP having a negative RDT result (control-subjects). Epi Info 7 software and SPSS 18.0 software were used with P< 0.05 as significance threshold. RESULTS: We recruited 234 subjects, 109 (46.6%) case-subjects and 125 control-subjects (53.4%). The associated factors found were: prematurity (P=0.03; OR=1.15; IC= 0.32 – 4.10), the non-use of LLIN (P=0.006; OR= 2.31; IC= 1.26 – 4.25), a history of hospitalization for malaria (P=0.007; OR= 2.19; IC= 1.23 – 3.89), IPTp-SP administration after 28 gestational weeks (P=0.001, OR= 3.55; IC= 1.7 – 7.61). After logistic regression, prematurity (P=0.024; OR=2.01; IC=1.1-3.7) and a history of hospitalization for malaria (P=0.001; OR=2.83; IC=1.50-5.4) remained associated with IPTp-SP failure. CONCLUSION: A history of hospitalization for malaria and prematurity are independent predictor of IPTp-SP failure. The African Field Epidemiology Network 2016-03-31 /pmc/articles/PMC4894739/ /pubmed/27303570 http://dx.doi.org/10.11604/pamj.2016.23.152.7936 Text en © Félix Essiben et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Essiben, Félix Foumane, Pascal de Nguefack, Marcelle Aurelie Tsafack Eko, Filbert Eko Njotang, Philip Nana Enow, Robinson Mbu Mboudou, Emile Telesphore Facteurs prédictifs de l’échec du Traitement Préventif Intermittent du paludisme à la sulfadoxine – pyriméthamine (TPIp-SP) dans une population de femmes enceintes à Yaoundé |
title | Facteurs prédictifs de l’échec du Traitement Préventif Intermittent du paludisme à la sulfadoxine – pyriméthamine (TPIp-SP) dans une population de femmes enceintes à Yaoundé |
title_full | Facteurs prédictifs de l’échec du Traitement Préventif Intermittent du paludisme à la sulfadoxine – pyriméthamine (TPIp-SP) dans une population de femmes enceintes à Yaoundé |
title_fullStr | Facteurs prédictifs de l’échec du Traitement Préventif Intermittent du paludisme à la sulfadoxine – pyriméthamine (TPIp-SP) dans une population de femmes enceintes à Yaoundé |
title_full_unstemmed | Facteurs prédictifs de l’échec du Traitement Préventif Intermittent du paludisme à la sulfadoxine – pyriméthamine (TPIp-SP) dans une population de femmes enceintes à Yaoundé |
title_short | Facteurs prédictifs de l’échec du Traitement Préventif Intermittent du paludisme à la sulfadoxine – pyriméthamine (TPIp-SP) dans une population de femmes enceintes à Yaoundé |
title_sort | facteurs prédictifs de l’échec du traitement préventif intermittent du paludisme à la sulfadoxine – pyriméthamine (tpip-sp) dans une population de femmes enceintes à yaoundé |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894739/ https://www.ncbi.nlm.nih.gov/pubmed/27303570 http://dx.doi.org/10.11604/pamj.2016.23.152.7936 |
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