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Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon
Congenital melanocytic nevus (CMN) is a neural crest-derived hamartoma, which appear at or soon after birth. CMN has a dynamic course and may show variable changes over time, including spontaneous involution. Spontaneous involution of CMN is a rare phenomenon and is often reported in association wit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Journal of Dermatopathology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894811/ https://www.ncbi.nlm.nih.gov/pubmed/26588343 http://dx.doi.org/10.1097/DAD.0000000000000311 |
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author | Lee, Noo Ri Chung, Hee-Chul Hong, Hannah Lee, Jin Wook Ahn, Sung Ku |
author_facet | Lee, Noo Ri Chung, Hee-Chul Hong, Hannah Lee, Jin Wook Ahn, Sung Ku |
author_sort | Lee, Noo Ri |
collection | PubMed |
description | Congenital melanocytic nevus (CMN) is a neural crest-derived hamartoma, which appear at or soon after birth. CMN has a dynamic course and may show variable changes over time, including spontaneous involution. Spontaneous involution of CMN is a rare phenomenon and is often reported in association with halo phenomenon or vitiligo. The mechanism of halo phenomenon is yet to be investigated but is suggested to be a destruction of melanocytes by immune responses of cytotoxic T cells or IgM autoantibodies. Here, the authors report an interesting case of spontaneously regressed medium-sized CMN with halo phenomenon and without vitiligo, which provides evidence that cytotoxic T cells account for the halo formation and pigmentary regression of CMN. |
format | Online Article Text |
id | pubmed-4894811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The American Journal of Dermatopathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-48948112016-06-21 Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon Lee, Noo Ri Chung, Hee-Chul Hong, Hannah Lee, Jin Wook Ahn, Sung Ku Am J Dermatopathol Extraordinary Case Report Congenital melanocytic nevus (CMN) is a neural crest-derived hamartoma, which appear at or soon after birth. CMN has a dynamic course and may show variable changes over time, including spontaneous involution. Spontaneous involution of CMN is a rare phenomenon and is often reported in association with halo phenomenon or vitiligo. The mechanism of halo phenomenon is yet to be investigated but is suggested to be a destruction of melanocytes by immune responses of cytotoxic T cells or IgM autoantibodies. Here, the authors report an interesting case of spontaneously regressed medium-sized CMN with halo phenomenon and without vitiligo, which provides evidence that cytotoxic T cells account for the halo formation and pigmentary regression of CMN. The American Journal of Dermatopathology 2015-12 2015-11-20 /pmc/articles/PMC4894811/ /pubmed/26588343 http://dx.doi.org/10.1097/DAD.0000000000000311 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. |
spellingShingle | Extraordinary Case Report Lee, Noo Ri Chung, Hee-Chul Hong, Hannah Lee, Jin Wook Ahn, Sung Ku Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon |
title | Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon |
title_full | Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon |
title_fullStr | Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon |
title_full_unstemmed | Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon |
title_short | Spontaneous Involution of Congenital Melanocytic Nevus With Halo Phenomenon |
title_sort | spontaneous involution of congenital melanocytic nevus with halo phenomenon |
topic | Extraordinary Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894811/ https://www.ncbi.nlm.nih.gov/pubmed/26588343 http://dx.doi.org/10.1097/DAD.0000000000000311 |
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