A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state

Bacterial members of the neurotransmitter:sodium symporter (NSS) family perform Na(+)-dependent amino-acid uptake and extrude H(+) in return. Previous NSS structures represent intermediates of Na(+)/substrate binding or intracellular release, but not the inward-to-outward return transition. Here we...

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Detalles Bibliográficos
Autores principales: Malinauskaite, Lina, Said, Saida, Sahin, Caglanur, Grouleff, Julie, Shahsavar, Azadeh, Bjerregaard, Henriette, Noer, Pernille, Severinsen, Kasper, Boesen, Thomas, Schiøtt, Birgit, Sinning, Steffen, Nissen, Poul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894957/
https://www.ncbi.nlm.nih.gov/pubmed/27221344
http://dx.doi.org/10.1038/ncomms11673

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