NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells

Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to mice induces skin inflammation that exhibits many aspects of psoriasis, an inflammatory human skin disease. Here we show that mice depleted of B cells or bearing interleukin (IL)-10-deficient B cells show a fulmi...

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Detalles Bibliográficos
Autores principales: Alrefai, Hani, Muhammad, Khalid, Rudolf, Ronald, Pham, Duong Anh Thuy, Klein-Hessling, Stefan, Patra, Amiya K., Avots, Andris, Bukur, Valesca, Sahin, Ugur, Tenzer, Stefan, Goebeler, Matthias, Kerstan, Andreas, Serfling, Edgar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894959/
https://www.ncbi.nlm.nih.gov/pubmed/27222343
http://dx.doi.org/10.1038/ncomms11724

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