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HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice
Accumulating evidence suggests a critical role for epigenetic regulations in long term memory (LTM) formation. Among them, post-translational modifications of proteins, as histone acetylation, are an important regulator of chromatin remodelling and gene transcription. While the implication of histon...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895233/ https://www.ncbi.nlm.nih.gov/pubmed/27270584 http://dx.doi.org/10.1038/srep27015 |
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author | Villain, Hélène Florian, Cédrick Roullet, Pascal |
author_facet | Villain, Hélène Florian, Cédrick Roullet, Pascal |
author_sort | Villain, Hélène |
collection | PubMed |
description | Accumulating evidence suggests a critical role for epigenetic regulations in long term memory (LTM) formation. Among them, post-translational modifications of proteins, as histone acetylation, are an important regulator of chromatin remodelling and gene transcription. While the implication of histone acetylation in memory consolidation is widely accepted, less is known about its role in memory reconsolidation i.e. during memory restabilization after its reactivation. In the present study, we investigated the role of histone acetylation during the initial consolidation and the reconsolidation of spatial memory, using a weak massed learning procedure in the Morris water maze paradigm in mice. Usually a weak learning is sufficient for short term memory (STM) formation, but insufficient to upgrade STM to LTM. We found that promoting histone acetylation through intra-hippocampal infusion of a class I selective histone deacetylase (HDAC) inhibitor immediately after a subthreshold spatial learning improved LTM but not STM retention. More importantly, inhibiting HDAC activity after the reactivation of a weak memory promoted specifically LTM reconsolidation without affecting post-reactivation STM. These findings argue in favour of an important role for histone acetylation in memory consolidation, and more particularly during the reconsolidation of spatial memory in mice. |
format | Online Article Text |
id | pubmed-4895233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48952332016-06-10 HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice Villain, Hélène Florian, Cédrick Roullet, Pascal Sci Rep Article Accumulating evidence suggests a critical role for epigenetic regulations in long term memory (LTM) formation. Among them, post-translational modifications of proteins, as histone acetylation, are an important regulator of chromatin remodelling and gene transcription. While the implication of histone acetylation in memory consolidation is widely accepted, less is known about its role in memory reconsolidation i.e. during memory restabilization after its reactivation. In the present study, we investigated the role of histone acetylation during the initial consolidation and the reconsolidation of spatial memory, using a weak massed learning procedure in the Morris water maze paradigm in mice. Usually a weak learning is sufficient for short term memory (STM) formation, but insufficient to upgrade STM to LTM. We found that promoting histone acetylation through intra-hippocampal infusion of a class I selective histone deacetylase (HDAC) inhibitor immediately after a subthreshold spatial learning improved LTM but not STM retention. More importantly, inhibiting HDAC activity after the reactivation of a weak memory promoted specifically LTM reconsolidation without affecting post-reactivation STM. These findings argue in favour of an important role for histone acetylation in memory consolidation, and more particularly during the reconsolidation of spatial memory in mice. Nature Publishing Group 2016-06-07 /pmc/articles/PMC4895233/ /pubmed/27270584 http://dx.doi.org/10.1038/srep27015 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Villain, Hélène Florian, Cédrick Roullet, Pascal HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice |
title | HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice |
title_full | HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice |
title_fullStr | HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice |
title_full_unstemmed | HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice |
title_short | HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice |
title_sort | hdac inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895233/ https://www.ncbi.nlm.nih.gov/pubmed/27270584 http://dx.doi.org/10.1038/srep27015 |
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