Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome

This review summarizes a recent finding regarding the intrinsic canonical Notch signaling pathway in regulating normal ocular surface morphogenesis and its role in the pathogenesis of goblet cell deficiency-associated keratoconjunctivitis sicca (KCS, or dry eye). Specifically, we used novel transgen...

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Autor principal: Liu, Chia-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895251/
https://www.ncbi.nlm.nih.gov/pubmed/26818247
http://dx.doi.org/10.1186/s12886-015-0136-6
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author Liu, Chia-Yang
author_facet Liu, Chia-Yang
author_sort Liu, Chia-Yang
collection PubMed
description This review summarizes a recent finding regarding the intrinsic canonical Notch signaling pathway in regulating normal ocular surface morphogenesis and its role in the pathogenesis of goblet cell deficiency-associated keratoconjunctivitis sicca (KCS, or dry eye). Specifically, we used novel transgenic mice to investigate the mechanism of how the Notch1 activation may serve as the upstream control of expression of transcription factors Krüppel-like factors 4 or 5 (Klf4 or Klf5) which in turn controls goblet cell differentiation and activates mucin 5/ac synthesis during ocular surface morphogenesis.
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spelling pubmed-48952512016-06-10 Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome Liu, Chia-Yang BMC Ophthalmol Proceedings This review summarizes a recent finding regarding the intrinsic canonical Notch signaling pathway in regulating normal ocular surface morphogenesis and its role in the pathogenesis of goblet cell deficiency-associated keratoconjunctivitis sicca (KCS, or dry eye). Specifically, we used novel transgenic mice to investigate the mechanism of how the Notch1 activation may serve as the upstream control of expression of transcription factors Krüppel-like factors 4 or 5 (Klf4 or Klf5) which in turn controls goblet cell differentiation and activates mucin 5/ac synthesis during ocular surface morphogenesis. BioMed Central 2015-12-17 /pmc/articles/PMC4895251/ /pubmed/26818247 http://dx.doi.org/10.1186/s12886-015-0136-6 Text en © Liu. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Proceedings
Liu, Chia-Yang
Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome
title Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome
title_full Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome
title_fullStr Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome
title_full_unstemmed Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome
title_short Wakayama symposium: role of canonical Notch signaling in conjucntival goblet cell differentiation and dry eye syndrome
title_sort wakayama symposium: role of canonical notch signaling in conjucntival goblet cell differentiation and dry eye syndrome
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895251/
https://www.ncbi.nlm.nih.gov/pubmed/26818247
http://dx.doi.org/10.1186/s12886-015-0136-6
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