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The art of fin regeneration in zebrafish

The zebrafish fin provides a valuable model to study the epimorphic type of regeneration, whereby the amputated part of the appendage is nearly perfectly replaced. To accomplish fin regeneration, two reciprocally interacting domains need to be established at the injury site, namely a wound epitheliu...

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Detalles Bibliográficos
Autores principales: Pfefferli, Catherine, Jaźwińska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895310/
https://www.ncbi.nlm.nih.gov/pubmed/27499869
http://dx.doi.org/10.1002/reg2.33
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author Pfefferli, Catherine
Jaźwińska, Anna
author_facet Pfefferli, Catherine
Jaźwińska, Anna
author_sort Pfefferli, Catherine
collection PubMed
description The zebrafish fin provides a valuable model to study the epimorphic type of regeneration, whereby the amputated part of the appendage is nearly perfectly replaced. To accomplish fin regeneration, two reciprocally interacting domains need to be established at the injury site, namely a wound epithelium and a blastema. The wound epithelium provides a supporting niche for the blastema, which contains mesenchyme‐derived progenitor cells for the regenerate. The fate of blastemal daughter cells depends on their relative position with respect to the fin margin. The apical compartment of the outgrowth maintains its undifferentiated character, whereas the proximal descendants of the blastema progressively switch from the proliferation program to the morphogenesis program. A delicate balance between self‐renewal and differentiation has to be continuously adjusted during the course of regeneration. This review summarizes the current knowledge about the cellular and molecular mechanisms of blastema formation, and discusses several studies related to the regulation of growth and morphogenesis during fin regeneration. A wide range of canonical signaling pathways has been implicated during the establishment and maintenance of the blastema. Epigenetic mechanisms play a crucial role in the regulation of cellular plasticity during the transition between differentiation states. Ion fluxes, gap‐junctional communication and protein phosphatase activity have been shown to coordinate proliferation and tissue patterning in the caudal fin. The identification of the downstream targets of the fin regeneration signals and the discovery of mechanisms integrating the variety of input pathways represent exciting future aims in this fascinating field of research.
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spelling pubmed-48953102016-08-05 The art of fin regeneration in zebrafish Pfefferli, Catherine Jaźwińska, Anna Regeneration (Oxf) Reviews The zebrafish fin provides a valuable model to study the epimorphic type of regeneration, whereby the amputated part of the appendage is nearly perfectly replaced. To accomplish fin regeneration, two reciprocally interacting domains need to be established at the injury site, namely a wound epithelium and a blastema. The wound epithelium provides a supporting niche for the blastema, which contains mesenchyme‐derived progenitor cells for the regenerate. The fate of blastemal daughter cells depends on their relative position with respect to the fin margin. The apical compartment of the outgrowth maintains its undifferentiated character, whereas the proximal descendants of the blastema progressively switch from the proliferation program to the morphogenesis program. A delicate balance between self‐renewal and differentiation has to be continuously adjusted during the course of regeneration. This review summarizes the current knowledge about the cellular and molecular mechanisms of blastema formation, and discusses several studies related to the regulation of growth and morphogenesis during fin regeneration. A wide range of canonical signaling pathways has been implicated during the establishment and maintenance of the blastema. Epigenetic mechanisms play a crucial role in the regulation of cellular plasticity during the transition between differentiation states. Ion fluxes, gap‐junctional communication and protein phosphatase activity have been shown to coordinate proliferation and tissue patterning in the caudal fin. The identification of the downstream targets of the fin regeneration signals and the discovery of mechanisms integrating the variety of input pathways represent exciting future aims in this fascinating field of research. John Wiley and Sons Inc. 2015-05-19 /pmc/articles/PMC4895310/ /pubmed/27499869 http://dx.doi.org/10.1002/reg2.33 Text en © 2015 The Authors. Regeneration published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Pfefferli, Catherine
Jaźwińska, Anna
The art of fin regeneration in zebrafish
title The art of fin regeneration in zebrafish
title_full The art of fin regeneration in zebrafish
title_fullStr The art of fin regeneration in zebrafish
title_full_unstemmed The art of fin regeneration in zebrafish
title_short The art of fin regeneration in zebrafish
title_sort art of fin regeneration in zebrafish
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895310/
https://www.ncbi.nlm.nih.gov/pubmed/27499869
http://dx.doi.org/10.1002/reg2.33
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