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Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish

An unresolved mystery in the field of spinal muscular atrophy (SMA) is why a reduction of the ubiquitously expressed Smn protein causes defects mostly in motoneurons. We addressed the possibility that this restricted vulnerability stems from elevated Smn expression in motoneurons. To explore this, w...

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Detalles Bibliográficos
Autores principales:	Spiró, Zoltán, Koh, Angela, Tay, Shermaine, See, Kelvin, Winkler, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895340/ https://www.ncbi.nlm.nih.gov/pubmed/27273160 http://dx.doi.org/10.1038/srep27470

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