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Predicting transcription factor site occupancy using DNA sequence intrinsic and cell-type specific chromatin features

BACKGROUND: Understanding the mechanisms by which transcription factors (TF) are recruited to their physiological target sites is crucial for understanding gene regulation. DNA sequence intrinsic features such as predicted binding affinity are often not very effective in predicting in vivo site occu...

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Detalles Bibliográficos
Autores principales: Kumar, Sunil, Bucher, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895346/
https://www.ncbi.nlm.nih.gov/pubmed/26818008
http://dx.doi.org/10.1186/s12859-015-0846-z