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A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs
Paclitaxel is a commonly used chemotherapeutic agent with a broad spectrum of activity against cancers in humans. In 1992, paclitaxel was approved by the U.S. Food and Drug Administration (FDA) as Taxol(®) for use in advanced ovarian cancer. Two years later, it was approved for the treatment of meta...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895360/ https://www.ncbi.nlm.nih.gov/pubmed/26179168 http://dx.doi.org/10.1111/jvim.12596 |
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author | Khanna, C. Rosenberg, M. Vail, D. M. |
author_facet | Khanna, C. Rosenberg, M. Vail, D. M. |
author_sort | Khanna, C. |
collection | PubMed |
description | Paclitaxel is a commonly used chemotherapeutic agent with a broad spectrum of activity against cancers in humans. In 1992, paclitaxel was approved by the U.S. Food and Drug Administration (FDA) as Taxol(®) for use in advanced ovarian cancer. Two years later, it was approved for the treatment of metastatic breast cancer. Paclitaxel was originally isolated from the bark of the Pacific yew tree, Taxus brevifolia in 1971. Taxanes are a family of microtubule inhibitors. As a member of this family, paclitaxel suppresses spindle microtubule dynamics. This activity results in the blockage of the metaphase‐anaphase transitions, and ultimately in the inhibition of mitosis, and induction of apoptosis in a wide spectrum of cancer cells. Additional anticancer activities of paclitaxel have been defined that are independent of these effects on the microtubules and may include the suppression of cell proliferation as well as antiangiogenic effects. Based on its targeting of a fundamental feature of the cancer phenotype, the mitotic complex, it is not surprising that paclitaxel has been found to be active in a wide variety of cancers in humans. This review summarizes the evidence in support of paclitaxel's broad anticancer activity and introduces the rationale for, and the progress in development of novel formulations of paclitaxel that may preferentially target cancers and that are not associated with the risks for hypersensitivity in dogs. Of note, a novel nanoparticle formulation of paclitaxel that substantially limits hypersensitivity was recently given conditional approval by the FDA Center for Veterinary Medicine for use in dogs with resectable and nonresectable squamous cell carcinoma and nonresectable stage III, IV and V mammary carcinoma. |
format | Online Article Text |
id | pubmed-4895360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48953602016-06-22 A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs Khanna, C. Rosenberg, M. Vail, D. M. J Vet Intern Med Small Animal Paclitaxel is a commonly used chemotherapeutic agent with a broad spectrum of activity against cancers in humans. In 1992, paclitaxel was approved by the U.S. Food and Drug Administration (FDA) as Taxol(®) for use in advanced ovarian cancer. Two years later, it was approved for the treatment of metastatic breast cancer. Paclitaxel was originally isolated from the bark of the Pacific yew tree, Taxus brevifolia in 1971. Taxanes are a family of microtubule inhibitors. As a member of this family, paclitaxel suppresses spindle microtubule dynamics. This activity results in the blockage of the metaphase‐anaphase transitions, and ultimately in the inhibition of mitosis, and induction of apoptosis in a wide spectrum of cancer cells. Additional anticancer activities of paclitaxel have been defined that are independent of these effects on the microtubules and may include the suppression of cell proliferation as well as antiangiogenic effects. Based on its targeting of a fundamental feature of the cancer phenotype, the mitotic complex, it is not surprising that paclitaxel has been found to be active in a wide variety of cancers in humans. This review summarizes the evidence in support of paclitaxel's broad anticancer activity and introduces the rationale for, and the progress in development of novel formulations of paclitaxel that may preferentially target cancers and that are not associated with the risks for hypersensitivity in dogs. Of note, a novel nanoparticle formulation of paclitaxel that substantially limits hypersensitivity was recently given conditional approval by the FDA Center for Veterinary Medicine for use in dogs with resectable and nonresectable squamous cell carcinoma and nonresectable stage III, IV and V mammary carcinoma. John Wiley and Sons Inc. 2015-07-14 2015 /pmc/articles/PMC4895360/ /pubmed/26179168 http://dx.doi.org/10.1111/jvim.12596 Text en Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Small Animal Khanna, C. Rosenberg, M. Vail, D. M. A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs |
title | A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs |
title_full | A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs |
title_fullStr | A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs |
title_full_unstemmed | A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs |
title_short | A Review of Paclitaxel and Novel Formulations Including Those Suitable for Use in Dogs |
title_sort | review of paclitaxel and novel formulations including those suitable for use in dogs |
topic | Small Animal |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895360/ https://www.ncbi.nlm.nih.gov/pubmed/26179168 http://dx.doi.org/10.1111/jvim.12596 |
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